'In Vitro human skin testing; safety, allergy and contact sensitivity'

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This project proposal builds on the research conducted under a One North East Grant forResearch and Development awarded to Alcyomics in May 2010. Alcyomics research in 2010developed a unique assay (Skimune™) for allergy and contact sensitivity testing with two UKPatents pending (No GB No1020004.6;GB1115537.1). We now need to further validate theassay by comparing our results with current technologies, including an animal model system(LLNA) and to convert our UK patent into an international patent s. We will also aim tofurther validate the assay as a screening test using inflammatory cytokine measurements andT cell proliferation responses for up to 30 compounds which we will be able to correlate withthe skin explant assay and therefore potency. This is a novel aspect to the assay and deliverskey information about the safety of the compounds. In addition in collaboration with theNIBSC develop the assay further for use in predicting adverse reactions to therapeuticmonoclonal antibodies. Professor Ian Kimber, expert in skin sensitisation and toxicology, willalso act as advisor/consultant to the project.Pilot studies have proved positive and we nowrequire funds to develop and commercialise the assay to market.