OLFACTORY INFLUENCES ON PHYSIOLOGICAL PARAMETERS

描述：(改编自《调查者摘要》)：哺乳动物 一个人发出的化学信号，这些信号会改变生殖 共同特定受体的生理学(例如，青春期加速、发情 周期调节和从发情抑制中释放)被称为底物 信息素。荷尔蒙对共特异性化学信号的反应通常通过 增加黄体生成素(L.H)。类引发子信息素在细菌中的作用 人类包括月经周期的长度和时间的改变 使用男性或女性腋下分泌物提取物连续应用于 女性。 腋下分泌物似乎是人类气味来源的最佳候选者 化学传播器的性质。调查人员已经发起了一项 测定腋窝分泌物的化学性质和 建立一种可靠的评估信息素类化学成分的方法 活动。这项提案提供的数据表明， 男性腋窝提取物对女性志愿者鼻腔区域的影响 L.H.的脉搏模式。调查人员将使用这种生物测定来指导 活性腋叶提取物成分的分析研究。在……里面 此外，这项研究将有助于阐明涉及的神经内分泌机制。 对月经周期的嗅觉调节。理解这一点 机制可能提供对其他月经紊乱的洞察，这些月经紊乱是 与黄体生成素脉搏的细微变化有关，并被认为与此有关 对环境的影响，如下丘脑闭经和不孕症 由于黄体期不足。与此同时，调查人员将 继续研究腋臭化学。 调查人员计划确定ASOB1的结构并检查 在唾液和其他体液中发现45 kDa蛋白质以确定：(A)其 与顶分泌分泌ASOB1结构相似，(B)是否具有3M2H 与其结合；及(C)其携带的气味和顶分泌APOD(ASOB2) 在人类月经周期之后。

DESCRIPTION: (Adapted From The Investigator's Abstract): Mammalian chemical signals emitted by one individual which act to alter reproductive physiology in a cospecific recipient (e.g., acceleration of puberty, estrous cycle regulation and release from estrous suppression) are termed primer pheromones. Hormonal response to cospecific chemosignals often act by increasing luteinizing hormone (L.H). Primer-like pheromone effects in humans include an alteration of the length and timing of the menstrual cycle using serial applications of male or female axillary secretion extracts upon females. Axillary secretions appear to be the "best candidate" human odor source with chemical communicator properties. The investigators have initiated a program to determine the chemical character of axillary secretions and develop a reliable method to assess chemical constituents for pheromone-like activity. This proposal presents data which suggest that application of a male axillary extract to the nasal area of female volunteers, affects the pulse pattern of L.H. The investigators will employ this bioassay to guide an analytical study into the active axillary extract constituents. In addition, this study will help elucidate neuroendocrine mechanisms involved in olfactory modulation of the menstrual cycle. Understanding this mechanism may provide insight into other menstrual disorders which are associated with subtle alterations in LH pulsing and thought to be related to environmental influences such as hypothalamic amenorrhea and infertility due to an inadequate luteal phase. In parallel, the investigators will continue studies of axillar odor chemistry. The investigators plan to determine the structure of ASOB1 and examine the 45 kDa protein found in saliva and other body fluids to determine: (a) its structural similarity to apocrine secretion ASOB1, (b) whether it has 3M2H bound to it; and (c) whether odors carried by it and apocrine apoD (ASOB2) after the human menstrual cycle.