EPIDEMIOLOGY OF INTERSTITIAL CYSTITIS

间质性膀胱炎的流行病学

• 批准号: 2518471
• 负责人: GARY C. CURHAN
• 金额: $ 10.36万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-30 至 1999-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2518471
• 关键词: alcoholic beverage consumption; autoimmune disorder; disease /disorder proneness /risk; epidemiology; estrogens; female; human subject; interstitial cystitis; nutrition; progesterone; quality of life; questionnaires; urinary tract infection; women's health

This is a study of the epidemiology of interstitial cystitis among female participants of two large ongoing cohort studies: the Nurses' Health Study I (121,000 participants) and Nurses' Health Study II (116,000 participants). Interstitial Cystitis is a chronic, painful and disabling disease occurring predominantly in women but remarkably little is known about even such basic epidemiologic factors such as how common this disease is in the US and if it is increasing in frequency. The primary objective will be to determine the prevalence, incidence rates, and age distribution of interstitial cystitis in women. The secondary objective will be to examine the quality of life of women with interstitial cystitis, to compare this to the quality of life of healthy women and also to those with other chronic, painful conditions, and explore how the quality of life changes over a four year period. We will also examine the relation between interstitial cystitis and previously proposed risk factors including autoimmune diseases and multiple urinary tract infections. Finally, we will perform hypotheses generating analyses on proposed risk factors such as estrogen use, dietary factors, and alcohol consumption. Information on the presence of physician diagnosed interstitial cystitis will be collected by biennial mailed questionnaire. All self-reported cases will be confirmed by a supplementary form and a review of medical records. The diagnostic criteria will be that previously recommended by the NlDDK for research studies of interstitial cystitis. Information on exposure variables will also be collected by the biennial questionnaire. Baseline quality of life data, using the Medical Outcomes Study Short-Form 36, were collected within two years of the start of this study and will be updated four years later. Additional exposure information will be obtained by mailed questionnaire from all the cases and a random sample of 500 controls. During the five years of follow-up, over 110 cases of interstitial cystitis will be confirmed. The large sample size and long follow-up period will permit stable estimates of prevalence and incidence rates. In addition, this will provide a power of 0.86 to detect a relative risk of 1.8 for a dichotomous exposure. The morbidity of this chronic disease, the lack of essential epidemiologic information and the extremely limited knowledge regarding risk factors makes this an important public health issue. The proposed study will provide valuable data on the frequency of interstitial cystitis, the impact on the quality of life of women with this disease, and will generate hypotheses regarding risk factors for the development of this disease.

女性间质性膀胱炎流行病学研究 两项正在进行的大型队列研究的参与者：护士健康研究 I（121,000 名参与者）和护士健康研究 II（116,000 名参与者） 参与者）。间质性膀胱炎是一种慢性、痛苦且致残的疾病 该疾病主要发生在女性身上，但人们对此知之甚少 甚至关于这些基本的流行病学因素，例如这种情况的常见程度 该疾病在美国，并且其频率是否在增加。初级 目标是确定患病率、发病率和年龄 间质性膀胱炎在女性中的分布。次要目标 将检查具有间质性的女性的生活质量 膀胱炎，将其与健康女性的生活质量进行比较 那些患有其他慢性、痛苦疾病的人，并探索如何 生活质量在四年内发生变化。 我们还将检查 间质性膀胱炎与先前提出的风险之间的关系 因素包括自身免疫性疾病和多尿路 感染。最后，我们将进行假设生成分析 提议的危险因素，例如雌激素的使用、饮食因素和酒精 消耗。 有关医生诊断间质性膀胱炎的信息 将通过每两年邮寄一次的问卷调查的方式收集。全部自报 病例将通过补充表格和医疗审查来确认 记录。诊断标准将是之前推荐的 NlDDK 用于间质性膀胱炎的研究。有关信息 两年期调查问卷还将收集暴露变量。 使用医疗结果研究简表的基线生活质量数据 36，是在本研究开始后两年内收集的，并将 四年后更新。将获得额外的曝光信息 通过对所有案例进行邮寄问卷调查并随机抽取 500 名 控制。五年随访期间，共发现 110 余例 即可确诊间质性膀胱炎。样本量大、长度长 随访期将能够对患病率和发病率进行稳定的估计 费率。此外，这将提供 0.86 的功效来检测相对值 二分暴露的风险为 1.8。这种慢性病的发病率 疾病、缺乏必要的流行病学信息以及极端 关于风险因素的有限知识使其成为重要的公众 健康问题。拟议的研究将为以下方面提供有价值的数据： 间质性膀胱炎的发病率及其对生活质量的影响 患有这种疾病的女性，并将产生有关风险的假设 本病发生的因素。