Sex-related differences in incidence rates of nephrolithiasis

肾结石发病率的性别相关差异

• 批准号: 9178999
• 负责人: GARY C. CURHAN
• 金额: $ 14.85万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2021-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9178999
• 关键词: 18 year old; Accounting; Address; Adolescence; Adolescent and Young Adult; Adrenal hormone preparation; Adult; Age; Age-Years; Animals; Area; Ascorbic Acid; Award; Belief; Biological Markers; Body Size; Body Weight Changes; Body mass index; Calcium; Calcium Oxalate; Cardiovascular Diseases; Child; Citrates; Cohort Studies; Complement; Data; Degree program; Diabetes Mellitus; Diet; Dietary intake; Disease; Educational process of instructing; Elderly; Enrollment; Environment; Faculty; Female; Foundations; Frequencies; Funding; Future; Genetic; Goals; Gout; Grant; Health; Health Professional; Hour; Hyperparathyroidism; Hypertension; Incidence; Individual; Intake; K-Series Research Career Programs; Kidney Calculi; Kidney Diseases; Lead; Liquid substance; Manuscripts; Master' s Degree; Medical; Medicine; Mentors; Metabolism; Mid-Career Clinical Scientist Award (K24); Minerals; Minnesota; Modeling; Nephrolithiasis; Nephrology; Nurses' Health Study; Obesity; Oxalates; PTH gene; Participant; Patient Self-Report; Pattern; Potassium; Preparation; Prevalence; Prevention; Principal Investigator; Prospective Studies; Proteins; Public Health; Public Health Education; Recommendation; Recurrence; Reporting; Research; Research Personnel; Research Project Grants; Resources; Risk; Risk Factors; Role; Schools; Sex Characteristics; Skeleton; Staging; Techniques; Time; Training; United States National Institutes of Health; Urine; Woman; Work; age group; aged; base; calcium metabolism; career; case control; clinical investigation; clinical practice; cohort; early life exposure; emerging adult; follow-up; hearing impairment; high risk; improved; interest; lifestyle factors; male; men; modifiable risk; prevent; responsible research conduct; sex; sugar; sweetened beverage; woman health professional; young adult

ABSTRACT This application for a K24 award is to continue to support Dr. Gary Curhan, which will allow him to pursue his passion for mentoring junior investigators and to expand his work in clinical investigation. His research focuses on the prevention of common diseases by investigating scientifically and clinically important questions and exploring the role of modifiable factors, chiefly in the areas of nephrology and mineral metabolism. His long- term objectives remain focused on examining and challenging existing beliefs and commonly accepted practices, with the goal of motivating important changes in clinical practice and understanding to improve the health of individuals. Currently, he is the principal investigator or co-investigator of NIH-funded studies examining risk factors for a variety of conditions and topics including nephrolithiasis, oxalate nephropathy, primary hyperparathyroidism, gout, hearing loss, hypertension, cardiovascular disease, and interactions between adrenal and parathyroid hormones. He is studying diet, lifestyle factors, genetic contributions and biomarkers in large cohort studies based at the Channing Division of Network Medicine. Dr. Curhan has mentored over 45 individuals, and nearly all are in academic settings. He is currently the primary mentor for 6 midlevel/junior faculty nephrologists (4 are Principal Investigators of 2 NIH grants each, 1 with a K-award, and 1 with a foundation grant) and 3 nephrology fellows supported by NIH training grants or a foundation grant. He also serves as the secondary mentor to many junior faculty (including 3 with K-awards) and fellows. He is actively involved in teaching and mentoring in didactic Masters degree programs. The centerpiece of training of new mentees will be a mentored research project. In addition, the training will include didactic course work at the Harvard School of Public Health, training in the responsible conduct of research, the preparation of manuscripts and grants, and formal presentations in a stimulating and vibrant research environment. The award will support an examination of contributors to differences in incidence of nephrolithiasis between men and women and will also launch the first prospective study of risk factors for nephrolithiasis in adolescents and young adults, which will broaden our understanding of a variety of common conditions in addition to nephrolithiasis. Trainees will directly benefit by their involvement in this project and the multiple related ongoing projects of Dr. Curhan. Support by this K24 award will allow Dr. Curhan to continue to mentor individuals who wish to pursue careers in clinical investigation, particularly those interested in nephrology. These individuals will make important contributions to our understanding of disease and to improving the public’s health.

摘要 申请K24奖项是为了继续支持加里·柯尔汉博士，这将使他能够继续他的 热衷于指导初级研究人员，并扩大他在临床调查方面的工作。他的研究重点是 通过研究科学和临床上的重大问题来预防常见病 探索可调节因素的作用，主要是在肾脏病和矿物质代谢领域。他长长的- 任期目标仍然侧重于审查和挑战现有的信念和普遍接受的信念 实践，目标是推动临床实践和理解的重要变化，以改善 个人健康。目前，他是美国国立卫生研究院资助的研究的首席研究员或联合研究员 检查各种情况和主题的风险因素，包括肾结石、草酸肾病、 原发性甲状旁腺功能亢进症、痛风、听力损失、高血压、心血管疾病及其相互作用 肾上腺激素和甲状旁腺激素之间。他正在研究饮食、生活方式因素、遗传因素和 钱宁网络医学部大型队列研究中的生物标记物。科尔汉医生有 指导了超过45个人，几乎所有人都在学术环境中。他目前是6个孩子的主要导师 中级/初级教员肾病学家(4名首席研究员，分别获得2项NIH补助金，1项K奖，以及 1名有基金会资助的)和3名由NIH培训补助金或基金会资助的肾病学研究员。他 还担任许多初级教员(包括3名获得K奖的教员)和研究员的次要导师。他是 积极参与教学硕士学位课程的教学和指导工作。培训的核心内容是 新的受训者将是一个有指导的研究项目。此外，培训将包括教学课程工作在 哈佛大学公共卫生学院，负责进行研究的培训，准备 手稿和赠款，以及在激励和充满活力的研究环境中的正式报告。这个 该奖项将支持对导致男性肾结石发病率差异的因素进行调查。 还将启动第一项青少年肾结石风险因素的前瞻性研究，并将 年轻人，这将拓宽我们对各种常见疾病的了解，除了 肾结石。学员将直接受益于他们参与此项目以及正在进行的多个相关项目 科尔汉博士的项目。K24奖项的支持将使Curhan博士能够继续指导那些 希望从事临床研究工作，特别是对肾脏病感兴趣的人。这些人 将对我们了解疾病和改善公众健康做出重要贡献。