Sex-related differences in incidence rates of nephrolithiasis

摘要 这项K24奖的申请是为了继续支持加里柯汉博士，这将使他能够继续他的研究。 对指导初级研究者和扩大临床研究工作的热情。他的研究重点 通过调查科学和临床上的重要问题预防常见疾病， 探索可改变因素的作用，主要是在肾脏学和矿物质代谢领域。他的长- 学期目标仍然侧重于检查和挑战现有的信念， 实践，目标是激励临床实践和理解的重要变化，以提高 个人的健康。目前，他是NIH资助研究的主要研究者或共同研究者， 检查各种疾病和主题的风险因素，包括肾结石，草酸盐肾病， 原发性甲状旁腺功能亢进、痛风、听力损失、高血压、心血管疾病及其相互作用 肾上腺和甲状旁腺激素之间的联系他正在研究饮食，生活方式因素，遗传贡献和 生物标志物在大型队列研究的基础上，在网络医学的钱宁部门。柯汉医生 指导了超过45个人，几乎所有人都在学术环境中。他目前是6个主要的导师 中级/初级肾脏科医生（4名为主要研究者，各获得2项NIH赠款，1名获得K奖， 1人获得基金会赠款）和3名肾病学研究员获得NIH培训赠款或基金会赠款。他 同时也是许多初级教师（包括3名获得K奖的教师）和研究员的二级导师。他是 积极参与教学和指导教学硕士学位课程。训练的核心是 新的学员将是一个有指导的研究项目。此外，培训还将包括以下教学课程： 哈佛公共卫生学院，负责进行研究的培训， 手稿和赠款，并在一个刺激和充满活力的研究环境正式介绍。的 该奖项将支持对男性之间肾结石发病率差异的贡献者进行检查 还将启动第一项关于青少年肾结石风险因素的前瞻性研究， 年轻的成年人，这将扩大我们对各种共同条件的理解， 肾结石学员将直接受益于他们参与这个项目和多个相关的持续 Curhan博士的项目。K24奖的支持将使Curhan博士能够继续指导那些 希望从事临床研究，特别是对肾脏病学感兴趣的人。这些人 将对我们了解疾病和改善公众健康做出重要贡献。

ABSTRACT This application for a K24 award is to continue to support Dr. Gary Curhan, which will allow him to pursue his passion for mentoring junior investigators and to expand his work in clinical investigation. His research focuses on the prevention of common diseases by investigating scientifically and clinically important questions and exploring the role of modifiable factors, chiefly in the areas of nephrology and mineral metabolism. His long- term objectives remain focused on examining and challenging existing beliefs and commonly accepted practices, with the goal of motivating important changes in clinical practice and understanding to improve the health of individuals. Currently, he is the principal investigator or co-investigator of NIH-funded studies examining risk factors for a variety of conditions and topics including nephrolithiasis, oxalate nephropathy, primary hyperparathyroidism, gout, hearing loss, hypertension, cardiovascular disease, and interactions between adrenal and parathyroid hormones. He is studying diet, lifestyle factors, genetic contributions and biomarkers in large cohort studies based at the Channing Division of Network Medicine. Dr. Curhan has mentored over 45 individuals, and nearly all are in academic settings. He is currently the primary mentor for 6 midlevel/junior faculty nephrologists (4 are Principal Investigators of 2 NIH grants each, 1 with a K-award, and 1 with a foundation grant) and 3 nephrology fellows supported by NIH training grants or a foundation grant. He also serves as the secondary mentor to many junior faculty (including 3 with K-awards) and fellows. He is actively involved in teaching and mentoring in didactic Masters degree programs. The centerpiece of training of new mentees will be a mentored research project. In addition, the training will include didactic course work at the Harvard School of Public Health, training in the responsible conduct of research, the preparation of manuscripts and grants, and formal presentations in a stimulating and vibrant research environment. The award will support an examination of contributors to differences in incidence of nephrolithiasis between men and women and will also launch the first prospective study of risk factors for nephrolithiasis in adolescents and young adults, which will broaden our understanding of a variety of common conditions in addition to nephrolithiasis. Trainees will directly benefit by their involvement in this project and the multiple related ongoing projects of Dr. Curhan. Support by this K24 award will allow Dr. Curhan to continue to mentor individuals who wish to pursue careers in clinical investigation, particularly those interested in nephrology. These individuals will make important contributions to our understanding of disease and to improving the public’s health.