Factors influencing change in 24 hour urine composition

影响24小时尿液成分变化的因素

• 批准号: 8663895
• 负责人: GARY C. CURHAN
• 金额: $ 14.54万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8663895
• 关键词: Acid-Base Equilibrium; Acids; Address; African American; Age; Alkalies; Area; Award; Belief; Biological Markers; Body Size; Bone Density; Calcium; Calcium Oxalate; Cardiovascular Diseases; Caucasians; Caucasoid Race; Characteristics; Citrates; Clinical Trials; Cohort Studies; Collection; Complement; Cross-Sectional Studies; Data; Diabetes Mellitus; Diet; Dietary intake; Disease; Educational process of instructing; Environment; Equilibrium; Estrogens; Excretory function; Faculty; Funding; Future; Genetic; Goals; Gout; Grant; Health; Hormones; Hour; Hyperparathyroidism; Hypertension; Incidence; Individual; Intake; Intestinal Absorption; K-Series Research Career Programs; Kidney Calculi; Laboratories; Magnesium Citrate; Manuscripts; Master' s Degree; Menopausal Status; Menopause; Mentors; Metabolism; Mid-Career Clinical Scientist Award (K24); Minerals; Nephrolithiasis; Nephrology; Nurses' Health Study; Obesity; Osteoporosis; Participant; Pharmaceutical Preparations; Physiological; Postmenopause; Potassium; Premenopause; Preparation; Prevention; Principal Investigator; Process; Prospective Studies; Public Health; Public Health Education; Race; Race Relations; Reporting; Research; Research Personnel; Research Project Grants; Resources; Risk; Risk Factors; Role; Schools; Serum; Time; Training; United States National Institutes of Health; Update; Urate; Uric Acid; Urine; Urology; Woman; Work; absorption; base; bone turnover; calcium intake; calcium phosphate; career; clinical practice; falls; improved; insight; interest; lifestyle factors; programs; prospective; responsible research conduct; urinary

DESCRIPTION (provided by applicant): This application for a K24 award is to provide support to allow Dr. Gary Curhan to pursue his passion for mentoring junior investigators and to expand his work in clinical investigation. His research focuses on the prevention of common diseases by investigating scientifically and clinically important questions and exploring the role of modifiable factors, chiefly in the areas of nephrology and urology. His long-term objectives remain focused on examining and challenging existing beliefs and commonly accepted practices, with the goal of motivating important changes in clinical practice and understanding to improve the health of individuals. Currently, he is the principal investigator or co-investigator of NIH-funded studies examining risk factors for a variety of conditions including nephrolithiasis, hypertension, cardiovascular disease and gout. He is studying dietary, lifestyle factors, genetic contributions and biomarkers in large cohort studies based at the Channing Laboratory. Dr. Curhan has mentored over 25 individuals, all of whom are in academic settings. He is currently the primary mentor for 4 junior faculty nephrologists with K-awards and 4 nephrology fellows supported by NIH training grants. He is actively involved in teaching and mentoring in didactic Masters degree programs. The centerpiece of training of new mentees will be a mentored research project. In addition, the training will include didactic course work at the Harvard School of Public Health, training in the responsible conduct of research, the preparation of manuscripts and grants, and formal presentations in a stimulating and vibrant research environment. The award will support an examination of the impact of menopause on 24 hour urine composition, contributing to the understanding of a variety of common conditions including nephrolithiasis and osteoporosis. Trainees will directly benefit by their involvement in this project and the multiple related ongoing projects of Dr. Curhan. Support by this K24 award will allow Dr. Curhan to continue to mentor individuals who wish to pursue careers in clinical investigation, particularly those interested in nephrology and urology. These individuals will make important contributions to our understanding of disease and to improving the public's health.

描述（由申请人提供）：本次申请K24奖是为了支持Gary Curhan博士继续指导初级研究人员，并扩大他在临床研究方面的工作。他的研究重点是通过调查科学和临床重要问题以及探索可改变因素的作用来预防常见疾病，主要在肾脏病学和泌尿学领域。他的长期目标仍然集中在检查和挑战现有的信念和普遍接受的做法，目标是推动临床实践和理解的重要变化，以改善个人的健康。目前，他是美国国立卫生研究院资助的研究的主要研究者或共同研究者，研究各种疾病的风险因素，包括肾结石、高血压、心血管疾病和痛风。他正在钱宁实验室的大型队列研究中研究饮食、生活方式因素、遗传贡献和生物标志物。Curhan博士已经指导了超过25个人，他们都在学术环境中。他目前是4名获得k奖的初级肾病学家和4名获得NIH培训资助的肾病学研究员的主要导师。他积极参与教学和指导教学硕士学位课程。新学员培训的核心将是一个有指导的研究项目。此外，培训将包括哈佛公共卫生学院的教学课程、负责任的研究行为方面的培训、编写手稿和赠款，以及在激励和充满活力的研究环境中进行正式报告。该奖项将支持更年期对24小时尿液成分影响的研究，有助于了解各种常见疾病，包括肾结石和骨质疏松症。学员将直接受益于参与本项目和Curhan博士正在进行的多个相关项目。K24奖的支持将使Curhan博士能够继续指导那些希望从事临床研究的人，特别是那些对肾脏学和泌尿学感兴趣的人。这些人将对我们对疾病的理解和改善公众健康做出重要贡献。