Risk Factors for Hearing Loss

听力损失的危险因素

• 批准号: 8683145
• 负责人: GARY C. CURHAN
• 金额: $ 67.73万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8683145
• 关键词: 25-hydroxyvitamin D; Acetaminophen; Adverse effects; Affect; Alcohol consumption; Alcohols; Analgesics; Antioxidants; Aspirin; Audiometry; Benefits and Risks; Blood flow; Cochlea; Cohort Studies; Complex; Cross-Sectional Studies; Data; Development; Diagnosis; Disease; Dose; Drug usage; Ear; Environmental Risk Factor; Estrogen Receptors; Estrogen Therapy; Estrogens; Female; Folate; Folic Acid; Free Radical Scavengers; Genetic; Glutathione; Hearing; Hearing Tests; Hormones; Human; Ibuprofen; Intake; Labyrinth; Light; Maintenance; Measures; Medical; Menopausal Status; Menopause; Noise; Non-Steroidal Anti-Inflammatory Agents; Nurses' Health Study; Patient Self-Report; Personal Satisfaction; Plasma; Play; Population Study; Postmenopause; Progesterone; Progestins; Prospective Studies; Prostaglandin Inhibition; Public Health; Quality of life; Questionnaires; Risk; Risk Factors; Role; Safety; Sensory Disorders; Shapes; Staging; Supplementation; Vitamin A; Vitamin D Deficiency; Vitamins; Woman; aged; alcohol risk; cohort; demineralization; hearing impairment; insight; interdisciplinary approach; men; modifiable risk; primary outcome; prospective; salicylate; secondary outcome; social; standard measure

DESCRIPTION (provided by applicant): Hearing loss is the most common sensory disorder in the US, afflicting over 36 million people; thus, identification of modifiable risk factors is a vital public health issue. Strikingly, there are only limited prospective data on common and potentially modifiable risk factors for this highly prevalent, disabling condition. In addition to noise, factors potentially associated with risk of hearing loss include analgesics, vitamins, alcohol, menopausal status and postmenopausal hormone use. Aspirin, acetaminophen and ibuprofen are the three most commonly used drugs in the U.S. The ototoxic effects of high dose salicylates are well-known. Our preliminary studies in men found an increased risk of hearing loss with regular moderate use of aspirin, NSAIDs, and acetaminophen; however, this has not been prospectively studied in women. Vitamins, such as folate, A, C, D, and E, may play important roles in maintenance of hearing. Alcohol intake may have a variable impact on hearing, depending on the level of use. Additionally, estrogen may play a role in hearing function, thus menopausal status and postmenopausal hormone use may have important implications for hearing loss. We will examine these issues prospectively in large ongoing cohort studies involving over 150,000 women (Nurses' Health Studies I and II). To identify factors that can be modified at an early stage to conserve hearing, will examine audiometrically measured change in hearing sensitivity over 3 years in a subset of 3000 women in NHS II with either no or mild hearing loss. The secondary outcome will be selfreported professionally diagnosed hearing loss in the entire study population. We expect more than 5000 incident cases in each female cohort to be identified and confirmed by a supplementary questionnaire. We will use a multidisciplinary approach to examine the association between these common factors and the risk of hearing loss.

描述（由申请人提供）： 听力损失是美国最常见的感觉障碍，困扰着超过 3600 万人； 因此，确定可改变的风险因素是一个至关重要的公共卫生问题。引人注目的是，对于这种高度普遍的致残性疾病，关于常见和潜在可改变的风险因素的前瞻性数据非常有限。除了噪音之外，可能与听力损失风险相关的因素还包括镇痛药、维生素、酒精、绝经状态和绝经后激素的使用。 阿司匹林、对乙酰氨基酚和布洛芬是美国最常用的三种药物。高剂量水杨酸盐的耳毒性作用是众所周知的。我们对男性的初步研究发现，定期适度使用阿司匹林、非甾体抗炎药和对乙酰氨基酚会增加听力损失的风险。然而，尚未对女性进行前瞻性研究。维生素，如叶酸、A、C、D 和 E，可能在维持听力方面发挥重要作用。酒精摄入量可能会对听力产生不同的影响，具体取决于使用程度。此外，雌激素可能在听力功能中发挥作用，因此绝经状态和绝经后激素的使用可能对听力损失产生重要影响。我们将在涉及超过 150,000 名女性的大型持续队列研究中前瞻性地研究这些问题（护士健康研究 I 和 II）。 为了确定可以在早期阶段修改以保护听力的因素，我们将检查 NHS II 中 3000 名无听力损失或轻度听力损失的女性的听力敏感性在 3 年内的变化。次要结果将是整个研究人群自我报告的经专业诊断的听力损失。我们预计每个女性队列中将有超过 5000 起事件病例通过补充调查问卷得到识别和确认。我们将采用多学科方法来检查这些常见因素与听力损失风险之间的关联。