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PHOSPHORYLATION OF GAP JUNCTION PROTEINS

PHOSPHORYLATION OF GAP JUNCTION PROTEINS
间隙连接蛋白的磷酸化
批准号：
2024186
负责人：
PAUL D. LAMPE
金额：
$26.2万
依托单位：
FRED HUTCHINSON CANCER RESEARCH CENTER
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-05-01 至 2001-04-30
来源：
https://reporter.nih.gov/project-details/2024186
关键词：
Golgi apparatus HeLa cells SDS polyacrylamide gel electrophoresis animal tissue biological signal transduction cell cell interaction confocal scanning microscopy endoplasmic reticulum flow cytometry gap junctions high performance liquid chromatography image processing membrane channels mitogen activated protein kinase northern blottings phosphorylation protein biosynthesis protein degradation protein folding protein kinase C protein metabolism restriction endonucleases site directed mutagenesis tissue /cell culture western blottings

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中文摘要
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英文摘要
The general hypothesis to be tested is that phosphorylation of connexin43 and/or Cx45 regulates a variety of cellular functions. The experiments will address whether: (1) phosphorylation of Cx43 and Cx45 regulates the kinetics of connexin trafficking and/or oligomerization into connexons; (2) connexin phosphorylation regulates the intra- and intermembrane interactions that lead to gap junction channel formation; and (3) phosphorylation of Cx43 and Cx45 regulates gap junction degradation.
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Project 4: Risk stratification for pulmonary nodules detected by CT imaging using plasma and imaging biomarkers
  • 批准号：
    10436172
  • 项目类别：
  • 资助金额：
    $51.62万
  • 财政年份：
    2019
  • 负责人：
    PAUL D. LAMPE
  • 依托单位：
    FRED HUTCHINSON CANCER CENTER
Project 4: Risk stratification for pulmonary nodules detected by CT imaging using plasma and imaging biomarkers
  • 批准号：
    10601291
  • 项目类别：
  • 资助金额：
    $12.0万
  • 财政年份：
    2019
  • 负责人：
    PAUL D. LAMPE
  • 依托单位：
    FRED HUTCHINSON CANCER CENTER
Project 4: Risk stratification for pulmonary nodules detected by CT imaging using plasma and imaging biomarkers
Project 4: Risk stratification for pulmonary nodules detected by CT imaging using plasma and imaging biomarkers
  • 批准号：
    10700904
  • 项目类别：
  • 资助金额：
    $51.62万
  • 财政年份：
    2019
  • 负责人：
    PAUL D. LAMPE
  • 依托单位：
    FRED HUTCHINSON CANCER CENTER
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