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中文摘要
翻译
需要检验的一般假设是连接蛋白43的磷酸化 和/或Cx45调节多种细胞功能。这些实验 将讨论:(1)Cx43和Cx45的磷酸化是否调节 连接蛋白转运和/或寡聚为连接蛋白的动力学; 缝隙连接蛋白的磷酸化调控膜内和膜间 导致缝隙结沟道形成的相互作用;以及(3) Cx43和Cx45的磷酸化调节缝隙连接的降解。
英文摘要
The general hypothesis to be tested is that phosphorylation of connexin43 and/or Cx45 regulates a variety of cellular functions. The experiments will address whether: (1) phosphorylation of Cx43 and Cx45 regulates the kinetics of connexin trafficking and/or oligomerization into connexons; (2) connexin phosphorylation regulates the intra- and intermembrane interactions that lead to gap junction channel formation; and (3) phosphorylation of Cx43 and Cx45 regulates gap junction degradation.
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Project 4: Risk stratification for pulmonary nodules detected by CT imaging using plasma and imaging biomarkers
  • 批准号:
    10436172
  • 项目类别:
  • 资助金额:
    $51.62万
  • 财政年份:
    2019
  • 负责人:
    PAUL D. LAMPE
  • 依托单位:
Project 4: Risk stratification for pulmonary nodules detected by CT imaging using plasma and imaging biomarkers
  • 批准号:
    10601291
  • 项目类别:
  • 资助金额:
    $12.0万
  • 财政年份:
    2019
  • 负责人:
    PAUL D. LAMPE
  • 依托单位:
Project 4: Risk stratification for pulmonary nodules detected by CT imaging using plasma and imaging biomarkers
Project 4: Risk stratification for pulmonary nodules detected by CT imaging using plasma and imaging biomarkers
  • 批准号:
    10700904
  • 项目类别:
  • 资助金额:
    $51.62万
  • 财政年份:
    2019
  • 负责人:
    PAUL D. LAMPE
  • 依托单位:
海外基金