EFFICACY OF DRUG HOLIDAY FOR TREATMENT OF PARKINSON'S DISEASE

药物假期治疗帕金森病的功效

• 批准号: 6246763
• 负责人: THOMAS L DAVIS
• 金额: $ 3.1万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-01-27 至 1997-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6246763
• 关键词: Parkinson's disease; antiparkinson drugs; autonomic nervous system; clinical research; dopamine receptor; dosage; drug withdrawal; human subject; neurologic manifestations; quality of life

To investigate the tolerability, safety, and efficacy of "drug holiday" (withdrawal of antiparkinsonian medication) for the treatment of Parkinson's disease. Specifically we will investigate: 1. The acute effects of antiparkinsonian medication withdrawal on autonomic function. 2. The acute effects of a 4 day drug holiday on the responsiveness of the post synaptic dopamine receptor. 3. The chronic effects of a 4 day drug holiday on medication requirements, medication response, drug-induced hallucinations, sleep quality and quality of life in patients with complicated Parkinson's disease. 4. The safety of a 4 day drug holiday in patients with complicated Parkinson's disease.

研究"药物假期"的耐受性、安全性和有效性 （停用抗帕金森病药物）治疗 帕金森氏症。 具体来说，我们将调查： 1. 抗帕金森病药物停药的急性效应 自主神经功能 2. 4天停药期对药物反应性的急性影响 突触后多巴胺受体 3. 4天药物假期对药物治疗的慢性影响 需求，药物反应，药物引起的幻觉，睡眠 帕金森病并发症患者的生活质量 疾病 4. 4天停药期在复杂性高血压患者中的安全性 帕金森氏症。