DEEP BRAIN STIMULATION FOR THE TREATMENT OF DRUG RESISTANT TREMOR

深部脑刺激治疗耐药性震颤

• 批准号: 5219428
• 负责人: THOMAS L DAVIS
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5219428
• 关键词: clinical research; electrostimulus; human subject; human therapy evaluation; thalamus; tremor

For this study patients with drug resistant tremor (due to PD or essential tremor) are taken to the operating room. While they are awake, an electrode is placed within the ventrointermediate nucleus of the thalamus. Proper placement of this electrode requires physiologic testing whereby various areas of the thalamus are stimulated and the effects are recorded. Once an area can be found that allows adequate tremor suppression with minimal side effects, a permanent stimulator (much like a pacemaker) is implanted just under the skin just below the patient's clavicle. Once the stimulator is in place, the investigator may adjust stimulation parameters to provide the optimal benefit. Post-op evaluation of these patients includes an elaborate examination of their autonomic function within the CRC. In addition to aiding patients with medication-resistant tremor, this study provides us with information regarding various functional areas of the thalamus. In the near future, further studies are planned involving the stimulation of other areas of the basal ganglia for the treatment of other neurodegenerative diseases.

对于本研究中的耐药震颤患者（由于PD或 特发性震颤）被送往手术室。当他们醒来时， 将电极放置在脑的腹中间核内， 丘脑 该电极的正确放置需要生理 丘脑的各个区域受到刺激， 效果被记录下来。 一旦找到一个区域， 震颤抑制与最小的副作用，永久刺激器 (much就像心脏起搏器一样）被植入皮肤下方， 患者的锁骨。 一旦刺激器就位，研究人员 可以调整刺激参数以提供最佳益处。 这些患者的术后评估包括一个精心的检查 他们的自主神经功能。 除了帮助患有抗药性震颤的患者外， 研究为我们提供了有关各种功能领域的信息， 丘脑 在不久的将来，计划进行进一步的研究， 刺激基底神经节的其他区域以治疗 其他神经退行性疾病。