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EFFECT OF LOW PROTEIN INTAKE ON THE SYNTHESIS OF PLASMA PROTEINS

EFFECT OF LOW PROTEIN INTAKE ON THE SYNTHESIS OF PLASMA PROTEINS
低蛋白质摄入量对血浆蛋白合成的影响
批准号：
6247041
负责人：
NAOMI K FUKAGAWA
金额：
$2.44万
依托单位：
UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-01-23 至 1997-11-30
来源：
https://reporter.nih.gov/project-details/6247041
关键词：
albumins apolipoproteins blood proteins clinical research dietary proteins gas chromatography mass spectrometry glucose tolerance human subject insulin sensitivity /resistance nutrition related tag protein biosynthesis very low density lipoprotein

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中文摘要
翻译
这项研究的主要目的是确定胰岛素是否
英文摘要
The major aim of this study was to determine whether insulin resistance/glucose intolerance is related to the alterations in the fractional synthesis rates of albumin and apolipoprotein B. The approach used was the primed, constant infusion of L-{I,2-13C2} leucine with gas chromatography/mass spectrometry analysis of the 13C enrichment in hydrolyzed samples of apo B and albumin. Eight volunteers were studied between 12/1/95 and 5/7/96. Laboratory analyses are pending. Technical difficulties with VLDL isolation and mass spectrometry sensitivity in the albumin enrichments were encountered.
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