FUNCTION OF HORIZONTAL BASAL CELLS IN REGENERATION
FUNCTION OF HORIZONTAL BASAL CELLS IN REGENERATION
批准号:
2331267
负责人:
ERIC H HOLBROOK
金额:
$2.54万
依托单位国家:
美国
项目类别:
财政年份:
1997
资助国家:
美国
项目状态:
未结题
起止时间:
1997-09-30 至
中文摘要
嗅觉上皮具有替代死亡神经元的独特能力
英文摘要
The olfactory epithelium is unique in its ability to replace dying neurons
throughout life. The basal cells are responsible for this regenerative
capacity and can be divided in two groups, horizontal basal cells (HBCs)
and globose based cells (GBCs). The GBCs are considered the immediate
neuronal precursors that continually replace neurons that degenerate during
normal daily exposure to the environment. These cells also respond to
direct lesions of the epithelium, removal of their target organ, and
olfactory nerve transection by increasing their rate of proliferation and
production of neurons. The signals involved in triggering this increase in
proliferation after neuronal degeneration are unknown. The HBCs serve as
an intermediate signaling cell in the detection of neuronal degeneration
and initiation of regeneration. In addition, HBCs possess epidermal growth
factor (EGF) receptors that appear to the active during regeneration. The
proposed experiments are designed to examine the relationship between EGF
receptor activity of HBCs and the process of neuronal
degeneration/regeneration. To address this issue, surgical transection of
olfactory axons will be performed to initiate degeneration and regeneration
of olfactory receptor neurons. Immunocytochemistry and olfactory
epithelial explant cultures will also be utilized to examine this process.
Understanding the mechanisms involved in regeneration have long term
implications for reversing lesions to the nervous system.
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Enhancement of olfactory neuron survival and targeting via odorant exposure
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批准号:7590389
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项目类别:
-
资助金额:$19.0万
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财政年份:2006
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负责人:ERIC H HOLBROOK
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依托单位:
Enhancement of olfactory neuron survival and targeting via odorant exposure
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批准号:7792367
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项目类别:
-
资助金额:$19.0万
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财政年份:2006
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负责人:ERIC H HOLBROOK
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依托单位:
Enhancement of olfactory neuron survival and targeting via odorant exposure
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批准号:7379998
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项目类别:
-
资助金额:$19.0万
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财政年份:2006
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负责人:ERIC H HOLBROOK
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依托单位:
Enhancement of olfactory neuron survival and targeting via odorant exposure
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批准号:7216818
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项目类别:
-
资助金额:$19.12万
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财政年份:2006
-
负责人:ERIC H HOLBROOK
-
依托单位:
Enhancement of olfactory neuron survival and targeting via odorant exposure
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批准号:7079246
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项目类别:
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资助金额:$18.92万
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财政年份:2006
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负责人:ERIC H HOLBROOK
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依托单位: