Enhancement of olfactory neuron survival and targeting via odorant exposure

通过气味暴露增强嗅觉神经元的存活和定位

基本信息

  • 批准号:
    7590389
  • 负责人:
  • 金额:
    $ 19万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2006
  • 资助国家:
    美国
  • 起止时间:
    2006-04-01 至 2011-03-31
  • 项目状态:
    已结题

项目摘要

As an Otolaryngologist with a rich background in olfactory research and experience with the clinical assessment of olfactory disorders, I am positioned with the unique opportunity to combine these two disciplines in the search for medical therapies. This research career development plan consists of five years of mentored training through the design and implementation of the proposed project. Courses in new techniques, statistics, the ethics of animal and human studies, and the responsible conduct of research will supplement this training. The lab of Dr. James Schwob within Tufts University School of Medicine will provide the support, equipment, coursework, and overall educational environment to complete the research and training objectives of this proposal. My long-term career goal is to become an independent investigator within the area of olfaction at the Massachusetts Eye and Ear Infirmary in order to develop effective therapies for patients suffering from olfactory disorders. This research proposal will investigate the hypothesis that directed odorant exposure competitively enhances the survival and axonal targeting of receptor-specific olfactory neurons during recovery from lesion and that this effect occurs at the level of both the olfactory bulbs and olfactory epithelium. The hypothesis will be tested through three specific aims all utilizing the mouse model of recovery from methyl bromide exposure or olfactory nerve transection. Specific Aim 1 will look for the normalization in numbers of several different olfactory receptor subtypes within the epithelium after nares closure and will assess the effect of removing odor-induced activity on axon targeting. Specific Aim 2 will then show that selective repeated odorant exposure provides a competitive advantage in survival and axon targeting for the receptive olfactory neurons. Specific Aim 3 will then demonstrate that the enhanced survival observed in SA2 can occur without the target organ and supports the role of CREB in this process. In summary, this proposal determines the effect of repeated odorant exposure on the recovery of the sense of smell after injury. It provides additional areas of research on the mechanisms of how the system attempts to heal itself, and most importantly, the information gained from this work is relevant for the development of therapies aimed at reversing sense of smell disorders in humans.
作为一名具有丰富嗅觉研究背景和临床经验的耳鼻喉科医生, 评估嗅觉障碍,我定位与独特的机会,联合收割机这两个结合起来 寻找医学疗法的学科。该研究职业发展计划包括五年 通过设计和实施拟议项目,加强有指导的培训。新课程 技术、统计学、动物和人类研究的伦理以及负责任的研究行为将 补充这个训练。塔夫茨大学医学院的James Schwob博士的实验室将 提供支持,设备,课程和整体教育环境,以完成研究 和培训目标。我的长期职业目标是成为一名独立调查员 在马萨诸塞州眼耳医院的嗅觉区域内, 嗅觉障碍患者的治疗方法。 本研究将探讨定向气味暴露竞争性的假说 在损伤恢复过程中增强受体特异性嗅觉神经元的存活和轴突靶向 并且这种作用发生在嗅球和嗅上皮的水平上。的假设 将通过三个具体目标进行测试,所有目标都利用甲基溴恢复的小鼠模型。 暴露或嗅神经切断。具体目标1将寻找几个数量的标准化 不同的嗅觉受体亚型的上皮内鼻孔关闭后,并将评估的影响, 去除气味诱导的轴突靶向活性。具体目标2将显示,选择性重复 气味暴露为感受性嗅觉提供了生存和轴突靶向的竞争优势 神经元然后,具体目标3将证明,在SA2中观察到的存活率提高可以在没有 靶器官,并支持CREB在这一过程中的作用。 总之,该建议确定了重复气味暴露对恢复的影响。 受伤后的嗅觉它提供了额外的研究领域的机制,如何系统 试图治愈自己,最重要的是,从这项工作中获得的信息与 开发旨在逆转人类嗅觉障碍的疗法。

项目成果

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ERIC H HOLBROOK其他文献

ERIC H HOLBROOK的其他文献

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{{ truncateString('ERIC H HOLBROOK', 18)}}的其他基金

Enhancement of olfactory neuron survival and targeting via odorant exposure
通过气味暴露增强嗅觉神经元的存活和定位
  • 批准号:
    7792367
  • 财政年份:
    2006
  • 资助金额:
    $ 19万
  • 项目类别:
Enhancement of olfactory neuron survival and targeting via odorant exposure
通过气味暴露增强嗅觉神经元的存活和定位
  • 批准号:
    7379998
  • 财政年份:
    2006
  • 资助金额:
    $ 19万
  • 项目类别:
Enhancement of olfactory neuron survival and targeting via odorant exposure
通过气味暴露增强嗅觉神经元的存活和定位
  • 批准号:
    7216818
  • 财政年份:
    2006
  • 资助金额:
    $ 19万
  • 项目类别:
Enhancement of olfactory neuron survival and targeting via odorant exposure
通过气味暴露增强嗅觉神经元的存活和定位
  • 批准号:
    7079246
  • 财政年份:
    2006
  • 资助金额:
    $ 19万
  • 项目类别:
FUNCTION OF HORIZONTAL BASAL CELLS IN REGENERATION
水平基底细胞在再生中的功能
  • 批准号:
    2331267
  • 财政年份:
    1997
  • 资助金额:
    $ 19万
  • 项目类别:

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