Enhancement of olfactory neuron survival and targeting via odorant exposure
Enhancement of olfactory neuron survival and targeting via odorant exposure
批准号:
7379998
负责人:
ERIC H HOLBROOK
金额:
$19.0万
依托单位国家:
美国
项目类别:
财政年份:
2006
资助国家:
美国
项目状态:
已结题
起止时间:
2006-04-01 至 2011-03-31
关键词:
AblationAdultAfferent NeuronsAnimalsAreaAxonBilateralBinding ProteinsBiological AssayBreathingClinical assessmentsClosureConditionDailyDevelopmentDevelopment PlansDisciplineDoctor of MedicineEarElevationEnhancing LesionEnvironmentEpithelialEpitheliumEquipmentEthicsExcisionExposure toEyeFailureFiberGenetically Engineered MouseGoalsHealedHeterogeneityHumanInjuryLabelLaboratoriesLeadLesionMapsMassachusettsMeasuresMedicalMentorsMolecularMusNatural regenerationNerveNeuronsNumbersOdorsOlfaction DisordersOlfactory EpitheliumOlfactory NerveOrganOtolaryngologistPatientsPatternPeripheralPlayPopulationPositioning AttributeProcessReceptor ActivationRecoveryRegulationRelative (related person)ResearchResearch DesignResearch PersonnelResearch Project GrantsResearch ProposalsResearch TrainingRoleSensorySideSmell PerceptionSpecificityStimulusSurvival RateSystemTechniquesTestingTherapeuticTrainingUniversitiesVariantWorkair cleanercareerdesignexperiencehealinghuman studymedical schoolsmethyl bromidemouse modelnerve supplyneuronal survivalolfactory bulbolfactory disorderolfactory receptorolfactory stimulusreceptorreconstitutionreinnervationsizestatisticssuccesssynaptogenesistherapy development
中文摘要
作为一名具有丰富嗅觉研究背景和临床经验的耳鼻喉科医生
英文摘要
As an Otolaryngologist with a rich background in olfactory research and experience with the clinical
assessment of olfactory disorders, I am positioned with the unique opportunity to combine these two
disciplines in the search for medical therapies. This research career development plan consists of five years
of mentored training through the design and implementation of the proposed project. Courses in new
techniques, statistics, the ethics of animal and human studies, and the responsible conduct of research will
supplement this training. The lab of Dr. James Schwob within Tufts University School of Medicine will
provide the support, equipment, coursework, and overall educational environment to complete the research
and training objectives of this proposal. My long-term career goal is to become an independent investigator
within the area of olfaction at the Massachusetts Eye and Ear Infirmary in order to develop effective
therapies for patients suffering from olfactory disorders.
This research proposal will investigate the hypothesis that directed odorant exposure competitively
enhances the survival and axonal targeting of receptor-specific olfactory neurons during recovery from lesion
and that this effect occurs at the level of both the olfactory bulbs and olfactory epithelium. The hypothesis
will be tested through three specific aims all utilizing the mouse model of recovery from methyl bromide
exposure or olfactory nerve transection. Specific Aim 1 will look for the normalization in numbers of several
different olfactory receptor subtypes within the epithelium after nares closure and will assess the effect of
removing odor-induced activity on axon targeting. Specific Aim 2 will then show that selective repeated
odorant exposure provides a competitive advantage in survival and axon targeting for the receptive olfactory
neurons. Specific Aim 3 will then demonstrate that the enhanced survival observed in SA2 can occur without
the target organ and supports the role of CREB in this process.
In summary, this proposal determines the effect of repeated odorant exposure on the recovery of the
sense of smell after injury. It provides additional areas of research on the mechanisms of how the system
attempts to heal itself, and most importantly, the information gained from this work is relevant for the
development of therapies aimed at reversing sense of smell disorders in humans.
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会议论文
Enhancement of olfactory neuron survival and targeting via odorant exposure
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批准号:7590389
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项目类别:
-
资助金额:$19.0万
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财政年份:2006
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负责人:ERIC H HOLBROOK
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依托单位:
Enhancement of olfactory neuron survival and targeting via odorant exposure
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批准号:7792367
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项目类别:
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资助金额:$19.0万
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财政年份:2006
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负责人:ERIC H HOLBROOK
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依托单位:
Enhancement of olfactory neuron survival and targeting via odorant exposure
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批准号:7216818
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项目类别:
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资助金额:$19.12万
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财政年份:2006
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负责人:ERIC H HOLBROOK
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依托单位:
Enhancement of olfactory neuron survival and targeting via odorant exposure
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批准号:7079246
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项目类别:
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资助金额:$18.92万
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财政年份:2006
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负责人:ERIC H HOLBROOK
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依托单位:
FUNCTION OF HORIZONTAL BASAL CELLS IN REGENERATION
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批准号:2331267
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项目类别:
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资助金额:$2.54万
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财政年份:1997
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负责人:ERIC H HOLBROOK
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依托单位:
海外基金