FUNCTIONAL ANALYSIS OF ADIPOCYTE LIPID BINDING PROTEIN
FUNCTIONAL ANALYSIS OF ADIPOCYTE LIPID BINDING PROTEIN
批准号:
2015786
负责人:
ELIZABETH R SMITH
金额:
$2.86万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1996
资助国家:
美国
项目状态:
未结题
起止时间:
1996-12-08 至
中文摘要
所提出的研究的目标是确定
脂肪细胞脂肪酸结合蛋白(AFABP)在转运和
脂肪组织中脂肪酸的代谢。 脂肪酸贩运是
对脂肪组织储存和调动能量的能力至关重要,
并且脂肪酸代谢控制的不平衡伴随着肥胖,
胰岛素抵抗和糖尿病。 AFABP被认为是,但从来没有
直接证明,在脂肪的运输中起着重要的作用,
acids. 这项研究利用转基因小鼠,其中AFABP基因具有
被同源重组破坏,并且缺乏AFABP
蛋白 考虑到AFABP的丰度和组织特异性,
该蛋白质的缺乏将改变脂肪细胞脂质稳态。 使用
AFABP基因敲除小鼠,拟议的研究将调查的作用
AFABP在脂肪酸转运进入脂肪细胞和脂肪细胞内,以及
调节白色和棕色脂肪细胞的脂质代谢。
英文摘要
The goal of the proposed research is to determine the function of the
adipocyte fatty acid binding protein (AFABP) in the transport and
metabolism of fatty acids in adipose tissue. Fatty acid trafficking is
central to the ability of adipose tissue to store and mobilize energy,
and imbalances in the control of fatty acid metabolism accompany obesity,
insulin resistance, and diabetes. AFABP is believed, but have never been
directly proven, to be centrally important in the transport of fatty
acids. This study utilizes transgenic mice in which the AFABP gene has
been disrupted by homologous recombination and which lack the AFABP
protein. Given the abundance and tissue-specificity of AFABP, the
absence of the protein should alter adipocyte lipid homeostasis. Using
the AFABP-knockout mice, the proposed research will investigate the role
of AFABP in fatty acid transport into and within adipocytes, as well as
in the regulation of white and brown adipocyte lipid metabolism.
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批准号:2136394
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项目类别:
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资助金额:$1.14万
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财政年份:1996
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负责人:ELIZABETH R SMITH
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依托单位:
FUNCTIONAL ANALYSIS OF ADIPOCYTE LIPID BINDING PROTEIN
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批准号:2136395
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项目类别:
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资助金额:$1.23万
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财政年份:1996
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负责人:ELIZABETH R SMITH
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依托单位:
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批准号:2634173
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项目类别:
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资助金额:$3.05万
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财政年份:1996
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负责人:ELIZABETH R SMITH
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依托单位:
海外基金