MIRDP AT XAVIER UNIVERSITY OF LOUISIANA

路易斯安那州泽维尔大学 MIRDP

• 批准号: 2458394
• 负责人: HAROLD L KOMISKEY
• 金额: $ 41.77万
• 依托单位: XAVIER UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-08-14 至 1999-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2458394
• 关键词: drug addiction

APPLICANT'S ABSTRACT: The present application proposes research projects that will enhance the ability of our institution to conduct drug abuse research. The objectives of this proposal are: 1) to strengthen the institutional infrastructure, 2) To enhance the capability of individual faculty members to perform drug abuse research, and 3) To involve outstanding students in research in order to encourage them to pursue careers in drug abuse research. Two pilot projects and eight individual research subprojects are proposed. The pilot projects will enable the career development of two junior faculty members in drug abuse-related research. The eight drug abuse- related subprojects will enable faculty and outstanding students to accomplish the following specific aims. An evaluation of smoking cessation methods will be performed. The three-dimensional structure and electronic character of cocaine analogs will be determined. An endogenous ligand of the central benzodiazepine receptor will be identified. Slow release drug delivery systems will be developed for treating drug addictions. For example, biodegradable microcapsules containing buprenorphine will be developed and evaluated for release characteristics. In addition, an oral microcapsule formulation of amantidine will be developed and evaluated for release characteristics in in vitro and in vivo experiments. The prevalence of alcoholism in the black adolescent population of Louisiana relative to other ethnic adolescents will be contrasted with socioeconomic and cultural differences in onset of alcohol use, family attitudes and beliefs, peer pressure, school performance, and rational for drinking. New acyclic nucleotide analogs of anti-AIDS will be synthesized as potential anti-HIV agents for treatment of HIV-1 and 3'-azidothymidine (AZT) resistant HIV-1 strains in AIDS patients. Novel anti-Pneumocystis carinii drugs with less hepatotoxicity will be synthesized to enable improved drug therapy of alcoholic AIDS patients with liver damage.

申请人摘要： 本申请提出的研究项目将增强 我们机构进行药物滥用研究的能力。这个 这项建议的目标是： 1)加强机构基础设施建设， 2)提高教员个人的工作能力 药物滥用研究，以及 3)让优秀学生参与研究，以鼓励他们 追求药物滥用研究的事业。 两个试点项目和八个单独的研究子项目是 建议。 试点项目将帮助两名低年级学生实现职业发展 从事药物滥用相关研究的教职员工。八种药物滥用- 相关的子项目将使教职员工和优秀学生能够 实现以下具体目标。对吸烟的评价 将执行戒烟方法。立体结构 可卡因类似物的电学特征将被确定。一个 中枢苯二氮卓类受体的内源性配体将是 确认身份。缓释给药系统将被开发用于 治疗毒瘾。例如，可生物降解的微胶囊 将开发含有丁丙诺啡的药物并对其进行释放评估 特点。此外，一种口服微胶囊制剂 氨甲替丁将被开发并评估其释放特性 在体外和体内实验中。酒精中毒在中国的流行情况 相对于其他种族，路易斯安那州的黑人青少年人口 青少年将与社会经济和文化形成对比 饮酒开始时间、家庭态度和信仰、同伴的差异 压力，学业表现，以及饮酒的理性。新的无环 抗艾滋病的核苷酸类似物将被合成为潜在的抗HIV 抗HIV-1和抗叠氮胸苷(AZT)的HIV-1的治疗药物 艾滋病患者体内的毒株。新型抗卡氏肺孢子虫药物 将合成较少的肝脏毒性以实现改进的药物治疗 酒精性艾滋病患者的肝脏受损。