MIDARP AT XAVIER UNIVERSITY OF LOUISIANA

本申请书提出的研究项目将提高本机构进行药物滥用研究的能力。本建议的目标是：1)加强机构基础设施，以鼓励和促进更多的药物滥用研究活动；2)提高教职员工进行研究的能力，以促进独立的药物滥用研究事业；3)让优秀学生参与研究，以鼓励他们从事药物滥用研究事业。提出了4个试点项目和7个单独的研究子项目。试点项目和个别研究子项目的重点是针对与滥用药物有关的疾病状况进行分析分析和开发新的药物产品。确定可卡因类似物和多巴胺转运体配体的三维结构和电子特性，开发治疗药物成瘾的缓释药物输送系统。例如，将开发含有丁丙诺啡的可生物降解微胶囊，并评估其释放特性。此外，还将评估和优化一种可生物降解的微胶囊给药系统，该系统可释放一种对可卡因的催化抗体，以防止啮齿动物对可卡因的影响。在体内和体外的大麻素代谢，使用高度敏感和特异性分析可卡因在啮齿动物。在体内和体外的大麻素代谢，采用高灵敏度和特异性的分析方法，将研究高效液相色谱耦合串联质谱。尼古丁和吗啡对糖尿病鼠模型的影响。本研究将对艾滋病药物和成瘾治疗药物的新型阴离子化学递送偶联物的设计、合成和体内评价进行研究。新型抗卡氏肺囊虫药物不仅毒性小，而且具有神经保护作用，将为滥用兴奋剂的艾滋病患者提供更好的药物治疗。所要求的有限设备不仅将使拟议的研究得以进行，而且将加强体制基础设施。最后，修订后的续期申请将增加进行药物滥用研究的优秀学生的数量。

The present application proposes research projects that will enhance the ability of our institution to conduct drug abuse research. The objectives of this proposal are: 1) To strengthen the institutional infrastructure to encourage and foster increased research activity in drug abuse, 2) To enhance the capability of faculty and staff to perform research to facilitate independent drug abuse research careers, and 3) To involve outstanding students in research in order to encourage them to pursue careers in drug abuse research. Four pilot projects and seven individual research subprojects are proposed. The pilot projects and individual research subprojects focus on analytical analysis and development of new drug products for disease states related to drugs of abuse. The three-dimensional structure and electronic character of cocaine analogs and dopamine transporter ligands will be determined, Slow release drug delivery systems will be developed for treating drug addictions. For example, a biodegradable microcapsules containing buprenorphine will be developed and evaluated for release characteristics. In addition, a biodegradable microcapsule drug delivery system releasing a catalytic antibody to cocaine will be evaluated and optimized for preventing the effects of cocaine in rodents. The in vivo and in vitro cannabinoid metabolism, using highly sensitive and specific analytical cocaine in rodents. The in vivo and in vitro cannabinoid metabolism, using highly sensitive and specific analytical methodology will be studied using high performance liquid chromatography coupled to a tandem mass spectrometer. The influence of nicotine and morphine on a rodent model of diabetes mellitus. The design, synthesis and in vivo evaluation of novel anionic chemical delivery conjugates of selected AIDS drugs and addiction treatment drugs to the brain will be investigated. Novel anti-Pneumocystis carinii drugs with not only less toxicity, but neuroprotective action, will be synthesized to enable improved drug therapy of stimulant-abusing AIDS patients. The limited equipment requested will not only enable the proposed research to be carried out, but will strengthen the institutional infrastructure. Finally, this revised continuation application will increase the number of outstanding students conducting drug abuse research.