MIDARP AT XAVIER UNIVERSITY OF LOUISIANA

本申请提出的研究项目将加强我们机构进行药物滥用研究的能力。这项建议的目的是：1)加强体制基础设施，鼓励和促进更多的药物滥用研究活动；2)提高教职员工进行研究的能力，以促进独立的药物滥用研究事业；以及3)让优秀的学生参与研究，以鼓励他们从事药物滥用研究事业。提出了四个试点项目和七个单独的研究子项目。试点项目和个别研究子项目侧重于针对与滥用药物有关的疾病状态的新药产品的分析分析和开发。将确定可卡因类似物和多巴胺转运体配体的三维结构和电子性质，开发用于治疗药物成瘾的缓释药物释放系统。例如，将开发一种含有丁丙诺啡的可生物降解微囊，并对其释放特性进行评估。此外，将评估和优化可生物降解的微胶囊给药系统，释放对可卡因的催化抗体，以防止可卡因对啮齿动物的影响。体内和体外大麻素代谢，在啮齿动物中使用高度敏感和特异的可卡因分析。体内和体外大麻素代谢的研究，将使用高灵敏和特定的分析方法，使用与串联质谱仪相结合的高效液相色谱。尼古丁和吗啡对糖尿病啮齿动物模型的影响。将研究新型阴离子化学给药结合物的设计、合成和体内评价，这些药物包括艾滋病药物和成瘾治疗药物的脑内释放。新的抗卡氏肺孢子虫药物不仅毒性较小，而且具有神经保护作用，将被合成，以改善兴奋剂滥用艾滋病患者的药物治疗。所需的有限设备不仅将使拟议的研究得以进行，而且将加强体制基础设施。最后，修订后的延续申请将增加进行药物滥用研究的优秀学生的数量。

The present application proposes research projects that will enhance the ability of our institution to conduct drug abuse research. The objectives of this proposal are: 1) To strengthen the institutional infrastructure to encourage and foster increased research activity in drug abuse, 2) To enhance the capability of faculty and staff to perform research to facilitate independent drug abuse research careers, and 3) To involve outstanding students in research in order to encourage them to pursue careers in drug abuse research. Four pilot projects and seven individual research subprojects are proposed. The pilot projects and individual research subprojects focus on analytical analysis and development of new drug products for disease states related to drugs of abuse. The three-dimensional structure and electronic character of cocaine analogs and dopamine transporter ligands will be determined, Slow release drug delivery systems will be developed for treating drug addictions. For example, a biodegradable microcapsules containing buprenorphine will be developed and evaluated for release characteristics. In addition, a biodegradable microcapsule drug delivery system releasing a catalytic antibody to cocaine will be evaluated and optimized for preventing the effects of cocaine in rodents. The in vivo and in vitro cannabinoid metabolism, using highly sensitive and specific analytical cocaine in rodents. The in vivo and in vitro cannabinoid metabolism, using highly sensitive and specific analytical methodology will be studied using high performance liquid chromatography coupled to a tandem mass spectrometer. The influence of nicotine and morphine on a rodent model of diabetes mellitus. The design, synthesis and in vivo evaluation of novel anionic chemical delivery conjugates of selected AIDS drugs and addiction treatment drugs to the brain will be investigated. Novel anti-Pneumocystis carinii drugs with not only less toxicity, but neuroprotective action, will be synthesized to enable improved drug therapy of stimulant-abusing AIDS patients. The limited equipment requested will not only enable the proposed research to be carried out, but will strengthen the institutional infrastructure. Finally, this revised continuation application will increase the number of outstanding students conducting drug abuse research.