MIDARP AT XAVIER UNIVERSITY OF LOUISIANA

路易斯安那州泽维尔大学的 MIDARP

• 批准号: 6175649
• 负责人: HAROLD L KOMISKEY
• 金额: $ 39.35万
• 依托单位: XAVIER UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-08-14 至 2002-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6175649
• 关键词: drug addiction antagonist; drug design /synthesis /production

The present application proposes research projects that will enhance the ability of our institution to conduct drug abuse research. The objectives of this proposal are: 1) To strengthen the institutional infrastructure to encourage and foster increased research activity in drug abuse, 2) To enhance the capability of faculty and staff to perform research to facilitate independent drug abuse research careers, and 3) To involve outstanding students in research in order to encourage them to pursue careers in drug abuse research. Four pilot projects and seven individual research subprojects are proposed. The pilot projects and individual research subprojects focus on analytical analysis and development of new drug products for disease states related to drugs of abuse. The three-dimensional structure and electronic character of cocaine analogs and dopamine transporter ligands will be determined, Slow release drug delivery systems will be developed for treating drug addictions. For example, a biodegradable microcapsules containing buprenorphine will be developed and evaluated for release characteristics. In addition, a biodegradable microcapsule drug delivery system releasing a catalytic antibody to cocaine will be evaluated and optimized for preventing the effects of cocaine in rodents. The in vivo and in vitro cannabinoid metabolism, using highly sensitive and specific analytical cocaine in rodents. The in vivo and in vitro cannabinoid metabolism, using highly sensitive and specific analytical methodology will be studied using high performance liquid chromatography coupled to a tandem mass spectrometer. The influence of nicotine and morphine on a rodent model of diabetes mellitus. The design, synthesis and in vivo evaluation of novel anionic chemical delivery conjugates of selected AIDS drugs and addiction treatment drugs to the brain will be investigated. Novel anti-Pneumocystis carinii drugs with not only less toxicity, but neuroprotective action, will be synthesized to enable improved drug therapy of stimulant-abusing AIDS patients. The limited equipment requested will not only enable the proposed research to be carried out, but will strengthen the institutional infrastructure. Finally, this revised continuation application will increase the number of outstanding students conducting drug abuse research.

本申请提出了将增强我们机构进行药物滥用研究的能力的研究项目。这项建议的目的是：1）加强体制基础设施，以鼓励和促进增加药物滥用研究活动，2）提高教职员工进行研究的能力，以促进独立的药物滥用研究事业，以及3）让优秀学生参与研究，以鼓励他们从事药物滥用研究事业。 提出了四个试验项目和七个单独的研究分项目。试点项目和个别研究分项目的重点是针对与滥用药物有关的疾病状态进行分析和开发新的药物产品。确定可卡因类似物和多巴胺转运蛋白配体的三维结构和电子性质，开发用于治疗药物成瘾的药物缓释系统。例如，将开发含有丁丙诺啡的可生物降解的微胶囊，并评估其释放特性。此外，将评估和优化释放可卡因催化抗体的生物可降解微胶囊药物递送系统，以防止可卡因对啮齿动物的影响。在啮齿动物体内和体外大麻素代谢，使用高灵敏度和特异性分析可卡因。将使用高效液相色谱法和串联质谱仪研究体内和体外大麻素代谢，使用高灵敏度和特异性的分析方法。尼古丁和吗啡对糖尿病啮齿动物模型的影响。将研究所选艾滋病药物和成瘾治疗药物的新型阴离子化学递送缀合物的设计、合成和体内评价。新的抗卡氏肺孢子虫药物不仅毒性低，但神经保护作用，将被合成，使兴奋剂滥用艾滋病患者的药物治疗的改善。所要求的有限设备不仅将使拟议的研究得以进行，而且将加强体制基础设施。最后，修订后的继续申请将增加进行药物滥用研究的优秀学生人数。