Archaeal vesicles: new insights into viral evolution and DNA transfer

古菌囊泡：病毒进化和 DNA 转移的新见解

• 批准号: DE190101053
• 负责人: Dr Susanne Erdmann
• 金额: --
• 依托单位: University of Technology Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 2019-01-01
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE190101053
• 关键词: Archaeal; vesicles; new; insights; into

This project aims to determine the basis for plasmid and membrane vesicle generation and DNA transfer at the cellular and molecular level. Recent discovery of plasmid vesicles, which transfer plasmid DNA between host cells using viral capsid-like membrane vesicles, suggests they may be an evolutionary precursor for virus particles. The expected project outcomes include the first substantive characterisation of membrane vesicles in the phylum Euryarchaeota, how plasmid vesicles are generated and transmitted, and new insights into how viruses may evolve. This may lead to new avenues for preventing viral transmission and supporting development of new and improved applications biotechnology and the safe delivery of vaccines or genes in animals and humans.

该项目旨在确定质粒和膜囊泡产生以及细胞和分子水平上的DNA转移的基础。最近发现的质粒囊泡，使用病毒衣壳样膜囊泡在宿主细胞之间转移质粒DNA，表明它们可能是病毒颗粒的进化前体。预期的项目成果包括Euryarchaeota门中膜囊泡的第一个实质性特征，质粒囊泡如何产生和传播，以及对病毒如何进化的新见解。这可能会导致新的途径，以防止病毒传播和支持开发新的和改进的应用，生物技术和安全提供疫苗或基因在动物和人类。