PILOT STUDY LINKAGE ANALYSIS OF PROSTATE CANCER FAMILIES

描述 这项试验性研究的目的是确定有多个子女的家庭， 患有前列腺癌（即多发性家族）的成员，年龄小于65岁 岁的 最后的样本将包括100个亲属; 50个家庭 将在未来两年内确定。 本研究的具体目标 是1）分析这些人中前列腺癌的遗传方式， 家庭和2）评估样本发现疾病的能力 易感基因的遗传连锁分析。 长期目标是 在已确诊的前列腺癌中寻找易感基因 家庭 前列腺癌是男性最常见的癌症之一， 在北美，人们对此知之甚少。 目前的理解表明， 多种遗传改变在这种疾病的过程中是重要的。 彻底筛查多发性前列腺癌家族可以提供 用于遗传连锁分析以寻找疾病易感基因的样本 并独立确认研究结果， 发现某些染色体区域可能与发病机制有关 这种疾病。 此外，遗传性前列腺癌可以作为一种 在一般人群中的前列腺癌模型。 从愿意参加遗传连锁研究的家庭中， 将确定谱系。 前列腺癌患者的筛查 将开始在德克萨斯州的圣安东尼奥及其附近地区， 墨西哥裔美国人。 因此，预计样品将包括 几个墨西哥裔美国家庭。 样品的异质性可能是 由于包括不同的种族或确定先证者与广泛的 关于发病年龄的范围。 统计分析将把这一点纳入 考虑. 预计这项研究的结果将为以下方面奠定基础： 前列腺癌发病机制相关基因的系统研究 通过使用（1）候选基因方法和（2）“猎枪”方法， 感兴趣的特定染色体区域（即，检测基因的连锁）。 遗传标记均匀分布在特定染色体上的疾病 区域）。 这项研究将是第三项关于前列腺癌的连锁研究 在美国进行，它将有助于理解 前列腺癌的早期症状 它将分析大量的亲属关系， 提供了关于墨西哥裔美国人这种疾病的新信息， 一个对遗传性前列腺癌知之甚少的群体， 现在的时间

DESCRIPTION The object of this pilot study is to ascertain families with multiple members having prostate cancer (i.e. multiplex families) at less than 65 years of age. The final sample shall consist of 100 kinships; 50 families will be ascertained in the next two years. The specific aims for this study are 1) to analyze the mode of inheritance for prostate cancer in these families and 2) to evaluate the power of the sample for finding disease susceptibility genes with genetic linkage analysis. The long term goal is to search for susceptibility genes in the ascertained prostate cancer families. The etiology of prostate cancer, one of the most common cancers among males in North America, is poorly understood. Current understanding suggests that multiple genetic alterations are important in the process of this disease. A thorough screening of multiplex families with prostate cancer can provide a sample for genetic linkage analysis to find disease susceptibility genes for prostate cancer and to independently confirm results of studies having found that certain chromosomal regions might be involved in the pathogenesis of this disease. Additionally, hereditary prostate cancer can serve as a model for prostate cancer in the general population. From families willing to participate in a genetic linkage study, their pedigrees will be determined. The screening of prostate cancer patients will begin in San Antonio, Texas and its vicinity with over 50 percent Mexican American inhabitants. Thus, the sample is expected to consist of several Mexican American families. Heterogeneity of the sample might be caused by including different races or ascertaining probands with a wide range regarding age of onset. The statistical analysis will take this into consideration. It is anticipated that the results of the study will form the foundation for a systematic search of genes involved in the pathogenesis of prostate cancer by using (1) the candidate gene approach and (2) the "shot gun" approach for specific chromosomal regions of interest (i.e. testing linkage of the disease with genetic markers evenly distributed over specific chromosomal regions). This study will be the third linkage study on prostate cancer performed in the USA, it will contribute to the understanding of the etiology of prostate cancer. It will analyze a large number of kinships and provide new information on this disease in Mexican Americans, a minority group in which little is known about hereditary prostate cancer at the present time.