COBRE: UAF: CANHR EPIDEMIOLOGY & BIOINFORMATICS CORE

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。CANHR的一个关键需求是在科学研究设计、实施和分析方面提供强有力的支持，以发展和扩大资助的研究。流行病学和生物信息学（EB）核心通过咨询和培训、研究设计或数据库（DB）开发、样本量/功率估计和数据分析为研究项目提供科学和技术资源。此外，EB核心提供技术支持，如计算机硬件/软件，数据输入和现场工作准备。第五年的成果包括：A.建立了三个研究项目的数据和参与者反馈评价的四个数据库。为了提高研究人员通过网络访问研究数据的安全性和可访问性，我们正在将access数据库改为sql数据库。B.“实用程序”的发展使我们能够很容易地合并和传输数据进行统计分析。可用的功能数据库，实用程序，以及对硕士水平统计学家的额外招聘使得持续执行常规生物统计分析报告和为研究数据分析提供统计专业知识成为可能。C.在一个新村开展和管理数据收集工作（村庄定位、招聘和数据收集）。第二波数据收集是在我们的三个原始村庄进行的。这些努力涉及与当地实地研究助理和村领导/长老的密切合作。D.向一个村庄的传统理事会和社区成员传播初步研究结果。个别实验室结果和其他卫生措施通过信函向参与者散发，并由社区的卫生专业人员提供咨询。初步研究结果也在伯特利向育空-库斯科维姆保健公司和年度部落聚会上的村领导介绍。目前的工作：传播数据分析，资助申请的初步结果，科学文章，扩展谱系的连锁分析。此外，EB核心为拨款申请提供统计咨询。正在两个新村开展数据收集工作。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A critical need for CANHR is to develop and expand funded research with strong support in scientific study design, conduct, and analysis. The Epidemiology and Bioinformatics (EB) Core provides both scientific and technical resources for the research projects through consultation and training, study design or database (DB) development, sample size/power estimates, and data analyses. In addition, the EB Core offers ¿technical support,¿ such as computer hard/software, data entry, and fieldwork preparation. Year five accomplishments include: A. Establishment of four databases for data from the three research projects and the participant feedback evaluation. To increase security and access to the research data over the web by researchers, we are in the process of changing from an Access database to one using sql. B. The development of ¿utility programs¿ allows us to easily merge and transfer data for statistical analysis. The availability of functioning databases, utility programs, and the additional recruitment of a master's level statistician make it feasible to continuously perform routine biostatistical analyses for reports and provide statistical expertise for the analysis of the research data. C. Conducted and managed data collection efforts (village orientation, recruitment, and data collection) in one new village. Second wave data collection was conducted in three of our original villages. These efforts involved close collaboration with local field research assistants and village leaders/elders. D. Dissemination of preliminary research findings to the traditional council and community members in one village. Individual laboratory results and other health measures were disseminated via letters to participants, with a health professional available in the community for consultation. Preliminary research findings were also presented in Bethel to the Yukon-Kuskokwim Health Corporation and village leaders at the annual Tribal Gathering. Current efforts: Data analyses for dissemination, preliminary results for grant applications, scientific articles, linkage analyses of extended pedigrees. In addition, the EB Core provides statistical consulting for grant applications. Data collection efforts in two new villages are being conducted.