COBRE: UAF: CANHR EPIDEMIOLOGY & BIOINFORMATICS CORE

COBRE：UAF：CANHR 流行病学

• 批准号: 7381221
• 负责人: ROSEMARIE PLAETKE
• 金额: $ 8.54万
• 依托单位: UNIVERSITY OF ALASKA FAIRBANKS
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7381221
• 关键词: COBRE; UAF; CANHR; EPIDEMIOLOGY; BIOINFORMATICS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A critical need for CANHR is to develop and expand funded research with strong support in scientific study design, conduct, and analysis. The Epidemiology and Bioinformatics (EB) Core provides both scientific and technical resources for the research projects through consultation and training, study design or database (DB) development, sample size/power estimates, and data analyses. In addition, the EB Core offers ¿technical support,¿ such as computer hard/software, data entry, and fieldwork preparation. Year five accomplishments include: A. Establishment of four databases for data from the three research projects and the participant feedback evaluation. To increase security and access to the research data over the web by researchers, we are in the process of changing from an Access database to one using sql. B. The development of ¿utility programs¿ allows us to easily merge and transfer data for statistical analysis. The availability of functioning databases, utility programs, and the additional recruitment of a master's level statistician make it feasible to continuously perform routine biostatistical analyses for reports and provide statistical expertise for the analysis of the research data. C. Conducted and managed data collection efforts (village orientation, recruitment, and data collection) in one new village. Second wave data collection was conducted in three of our original villages. These efforts involved close collaboration with local field research assistants and village leaders/elders. D. Dissemination of preliminary research findings to the traditional council and community members in one village. Individual laboratory results and other health measures were disseminated via letters to participants, with a health professional available in the community for consultation. Preliminary research findings were also presented in Bethel to the Yukon-Kuskokwim Health Corporation and village leaders at the annual Tribal Gathering. Current efforts: Data analyses for dissemination, preliminary results for grant applications, scientific articles, linkage analyses of extended pedigrees. In addition, the EB Core provides statistical consulting for grant applications. Data collection efforts in two new villages are being conducted.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。CANHR的一个关键需求是在科学研究设计，实施和分析的大力支持下开发和扩大资助的研究。流行病学和生物信息学（EB）核心通过咨询和培训，研究设计或数据库（DB）开发，样本量/功效估计和数据分析为研究项目提供科学和技术资源。此外，EB Core还提供技术支持，如计算机硬件/软件、数据输入和实地工作准备。第五年的成绩包括：A。建立四个数据库，收集三个研究项目的数据和参与者的反馈评价。为了提高研究人员通过网络访问研究数据的安全性，我们正在将Access数据库更改为使用SQL的数据库。B。实用程序的开发使我们能够轻松地合并和传输数据进行统计分析。可用的功能数据库，实用程序，以及硕士水平的统计学家的额外招聘，使其能够持续进行报告的常规生物统计分析，并为研究数据的分析提供统计专业知识。C.在一个新的村庄开展和管理数据收集工作（村庄概况介绍、征聘和数据收集）。在我们最初的三个村庄进行了第二波数据收集。这些努力涉及与当地实地研究助理和村长/长老密切合作。D.向一个村庄的传统理事会和社区成员传播初步研究结果。个人实验室结果和其他健康措施通过信件传播给参与者，社区有一名保健专业人员可供咨询。还在贝瑟尔向育空-Kuskokwim保健公司和年度部落集会上的村领导人介绍了初步研究结果。目前的努力：传播数据分析，资助申请的初步结果，科学论文，扩展谱系的联系分析。此外，EB Core还为赠款申请提供统计咨询。目前正在两个新的村庄开展数据收集工作。