RESPIRATORY CARCINOGENESIS BY CHEMICAL AND PHYSICAL FACTORS

人类肺部病理学的研究继续进行，以确定 矽肺肺部病变伴有 肺泡II型上皮增生和腺瘤样病变， 邻近纤维化区域，以及它们与肺 腺癌 组织学材料进行了检查， 这项研究是与NIOSH和流行病学合作设计的， 程序，NCI，以表征上皮增生性病变 和肺癌的组织学类型在一个大的人口样本 来自德国萨克森地区的铀矿工人， 严重暴露于二氧化硅和/或辐射，特别是在20世纪50年代， 60年代 该人群包括15，000多例硅肺病例， 5，000例肺癌，其中暴露史和尸检 超过90%的案件都有记录。 组织学病变 在试点研究中进行了检查和分类盲目的几个 病理学家 进一步的研究继续描述了 在大鼠模型中由结晶二氧化硅引起的损伤， 硅肺相关的肺癌。

Studies of human lung pathology were continued in order to identify the conditions under which silicotic lung lesions are accompanied by alveolar type II epithelial hyperplasia and adenomatoid lesions, adjacent to areas of fibrosis, and their association with lung adenocarcinomas. Histological material was examined from a pilot study, designed in collaboration with NIOSH and with the Epidemiology Program, NCI, in order to characterize epithelial proliferative lesions and lung cancers by histologic type in a sample from a large population of uranium miners from the Saxony region in Germany, that received heavy exposures to silica and/or radiation especially in the 1950s and '60s. This population includes over 15,000 cases of silicosis and 5,000 cases of lung cancer, for which exposure histories and autopsy records are available for over 90% of cases. The histological lesions in the pilot study were examined and classified blindly by several pathologists. Further studies have continued to characterize the lesions induced by crystalline silica in the rat model for silicosis-associated lung carcinogenesis.