ALUMINUM IN ALZHEIMERS DISEASE

铝在阿尔茨海默病病因学中的作用仍然存在 由于该领域报告的相互矛盾的结果而引起争议。 固定和染色样本的测量，其中疾病相关 斑块和缠结可以被识别， 元素再分布和污染。 即使有一个 切片技术，其中斑块处于未固定、未染色的 切片可以从它们在两个相邻染色的 第二节，结构仍然存在不确定性，因此， 有意义的铝浓度。 一种改良的硫磺素染色剂的效果 阿尔茨海默病脑冷冻切片中元素分布的研究 利用能量色散X射线光谱学对组织进行了检查 (EDS)分析染色前后的菌斑组成。 这是 发现，虽然染色改变了整体组成， Al和其他元素如Si和Fe相对不变， 染色 基于这一发现，铝与牙菌斑的关系 在硫磺素染色的切片中研究结构。

The role of aluminum in the etiology of Alzheimer's disease remains controversial because of the contradictory results reported in the field. Measurements on fixed and stained samples in which disease-related plaques and tangles can be identified are criticized for possible elemental redistribution and contamination. Even with a sandwich-section technique, in which plaques in an unfixed, unstained section can be located from their position in two adjacent stained sections, uncertainty remains about structure and, therefore, also about meaningful Al concentrations. The effect of a modified thioflavin stain on elemental distributions in cryosections of Alzheimer's disease brain tissue has been examined, using energy- dispersive X-ray spectroscopy (EDS) to analyze plaque composition before and after staining. It was found that, although staining alters the overall composition, peaks for Al and other elements such as Si and Fe are relatively unchanged by staining. Based on this finding, the relationship of Al to plaque structure is being investigated in thioflavin-stained sections.