ELEMENTAL DISTRIBUTIONS IN CENTRAL NERVOUS SYSTEM TISSUES

中枢神经系统组织中的元素分布

• 批准号: 3978330
• 负责人: C R SWYT
• 金额: --
• 依托单位: DIVISION OF RESEARCH SERVICES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3978330
• 关键词: Alzheimer's disease; brain mapping; cerebral cortex; degenerative motor system disease; electron probe spectrometry; hippocampus; histopathology; human tissue; image processing; neurofibrillary tangles; sectioning

The occurrence of neurofibrillary tangles and plaques is common to a number of central nervous system disorders including Guamanian amyotrophic lateral sclerosis (ALS), parkinsonism with dementia (PD), and Alzheimer's disease. These NFTs and plaques contain nonessential metals and elevated levels of biological elements. Fixed and frozen thick sections of hippocampus and frontal cortex of human brain from subjects exhibiting symptoms of these diseases have been examined in the CAMECA MBX microprobe. Wave length dispersive x-ray spectrometry (WDS) performed at selected areas has provided both spectra and digital images showing the distribution of elements of interest in the specimens.

神经原纤维缠结和斑块的发生对于许多人来说很常见 中枢神经系统疾病，包括关岛肌萎缩侧索硬化症 硬化症（ALS）、帕金森病伴痴呆（PD）和阿尔茨海默病。 这些 NFT 和斑块含有非必需金属和较高水平的 生物元素。 固定并冷冻海马厚切片 表现出这些症状的受试者的人脑额叶皮层 疾病已在 CAMECA MBX 微探针中进行了检查。 波长 在选定区域进行的色散 X 射线光谱分析 (WDS) 提供了光谱和数字图像，显示了分布 样本中感兴趣的元素。