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ELEMENTAL DISTRIBUTIONS IN CENTRAL NERVOUS SYSTEM TISSUES

ELEMENTAL DISTRIBUTIONS IN CENTRAL NERVOUS SYSTEM TISSUES
中枢神经系统组织中的元素分布
批准号：
3978330
负责人：
C R SWYT
金额：
$0.0万
依托单位：
DIVISION OF RESEARCH SERVICES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3978330
关键词：
Alzheimer's disease brain mapping cerebral cortex degenerative motor system disease electron probe spectrometry hippocampus histopathology human tissue image processing neurofibrillary tangles sectioning

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中文摘要
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英文摘要
The occurrence of neurofibrillary tangles and plaques is common to a number of central nervous system disorders including Guamanian amyotrophic lateral sclerosis (ALS), parkinsonism with dementia (PD), and Alzheimer's disease. These NFTs and plaques contain nonessential metals and elevated levels of biological elements. Fixed and frozen thick sections of hippocampus and frontal cortex of human brain from subjects exhibiting symptoms of these diseases have been examined in the CAMECA MBX microprobe. Wave length dispersive x-ray spectrometry (WDS) performed at selected areas has provided both spectra and digital images showing the distribution of elements of interest in the specimens.
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  • 批准号：
    3959973
  • 项目类别：
  • 资助金额：
    $0.0万
  • 财政年份：
    --
  • 负责人：
    C R SWYT
  • 依托单位：
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  • 批准号：
    3937319
  • 项目类别：
  • 资助金额：
    $0.0万
  • 财政年份：
    --
  • 负责人：
    C R SWYT
  • 依托单位：
    DIVISION OF RESEARCH SERVICES
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