M AVIUM WALL STRUCTURES FROM AIDS PATIENTS

来自艾滋病患者的 M AVIUM 墙结构

• 批准号: 2751059
• 负责人: DELPHI CHATTERJEE
• 金额: $ 2.52万
• 依托单位: COLORADO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-30 至 2000-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2751059
• 关键词: Mycobacterium avium; biomarker; carbohydrate biosynthesis; cell wall; chemical structure function; ethambutol; host organism interaction; mannans; structural biology; virulence

DESCRIPTION (Adapted from the Investigator's Abstract): The overall aim of the U.S. Principal Investigator's NIH Grant AI 37139 is to investigate the role of lipoarabinomanan (LAM) in the virulence and pathogenesis of tuberculosis and leprosy. Identification of truncated structural variants of LAM in ethambutol drug-resistant strains of mycobacteria has provided the PI with model compounds for both structural and functional studies aimed at defining the relevance of LAM in host-mycobacterial interactions. The present AIDS-FIRCA proposal is to investigate the structural features of LAM from clinical and laboratory strains of M. avium complex (MAC) that differ in colony morphology and drug resistance. Specifically, the proposal will address relationship of colony morphotypes, virulence and drug reasistance by defining the chemical nature of LAM from MAC, by examinig the effect of ethambutol on the arabinan biosynthesis in the cell wall of MAC, and by studying the biochemical markers that distinguish virulent and avirulent isolates.

描述（改编自研究者摘要）：总体目标 美国首席研究员NIH Grant AI 37139将调查 脂阿拉伯甘露聚糖（LAM）在大肠杆菌毒力和发病机制中的作用 肺结核和麻风病。 截短结构变体的鉴定 LAM在乙胺丁醇耐药分枝杆菌菌株中的作用提供了 PI与模型化合物的结构和功能研究，旨在 确定LAM在宿主-分枝杆菌相互作用中的相关性。 的 目前的AIDS-FIRCA建议是研究LAM的结构特征 从临床和实验室分离的M. Avium复合体（MAC）， 菌落形态和耐药性。 具体而言，该提案将 解决菌落形态、毒力和耐药性之间的关系 通过从MAC中定义LAM的化学性质，通过检查 乙胺丁醇对MAC细胞壁中阿拉伯聚糖生物合成的影响， 研究区分致病力和无毒力的生化标记 分离株