M AVIUM WALL STRUCTURES FROM AIDS PATIENTS

来自艾滋病患者的 M AVIUM 墙结构

• 批准号: 6044167
• 负责人: DELPHI CHATTERJEE
• 金额: $ 2.52万
• 依托单位: COLORADO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-30 至 2001-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6044167
• 关键词: Mycobacterium avium; biomarker; carbohydrate biosynthesis; cell wall; chemical structure function; ethambutol; host organism interaction; mannans; structural biology; virulence

DESCRIPTION (Adapted from the Investigator's Abstract): The overall aim of the U.S. Principal Investigator's NIH Grant AI 37139 is to investigate the role of lipoarabinomanan (LAM) in the virulence and pathogenesis of tuberculosis and leprosy. Identification of truncated structural variants of LAM in ethambutol drug-resistant strains of mycobacteria has provided the PI with model compounds for both structural and functional studies aimed at defining the relevance of LAM in host-mycobacterial interactions. The present AIDS-FIRCA proposal is to investigate the structural features of LAM from clinical and laboratory strains of M. avium complex (MAC) that differ in colony morphology and drug resistance. Specifically, the proposal will address relationship of colony morphotypes, virulence and drug reasistance by defining the chemical nature of LAM from MAC, by examinig the effect of ethambutol on the arabinan biosynthesis in the cell wall of MAC, and by studying the biochemical markers that distinguish virulent and avirulent isolates.

描述（根据调查员的摘要改编）： 美国首席调查员的NIH赠款AI 37139是调查 脂脂动曼（LAM）在毒力和发病机理中的作用 结核病和麻风病。 识别截短的结构变体 在埃achutol抗菌药物抗药性菌株中的lam的lam已提供了 具有模型化合物的PI，用于结构和功能研究 定义LAM在宿主 - 细菌相互作用中的相关性。 这 当前的艾滋病 - firca提案是研究LAM的结构特征 从鸟杆菌复合物（MAC）的临床和实验室菌株中 在菌落形态和耐药性中。 具体而言，该提议将 地址菌落形态型，毒力和药物保险的关系 通过确定MAC的LAM的化学性质 MAC细胞壁中的阿拉伯生物合成上的ethambutol，通过 研究区分有毒和无毒的生化标记 分离物。