ROLE(S) OF THE VENTROMEDIAL NUCLEI IN HPA AXIS FUNCTION

这些实验的目的是为了了解腹内侧部如何 核团(VMN)引导神经和激素代谢信号，可能发挥一种 在临床高血压、肥胖症和糖尿病的发生发展中的作用。 我们实验室最近的研究表明，下丘脑的调节- 垂体-肾上腺(HPA)轴功能嵌入较大的下丘脑 系统调节能量平衡。下丘脑的VMN是完整的 摄食行为、体重、肾上腺皮质活动和胰岛素 分泌物。我们建议研究VMN在HPA中的综合作用 轴、摄食和胰岛素分泌；我们将检验以下假设 从边缘和内脏输入到VMN的输入涉及到。首先，我们 将调查VMN在HPA功能的皮质类固醇反馈中的作用。 第二，我们将测量HPA中昼夜节律的程度 活动，以及禁食对这些节律的影响，是由VMN- 下丘脑室旁核(PVN)的驱动输入，它包含 神经内分泌运动输出到HPA轴。最后，我们将努力 确定盐皮质激素受体是否导向皮质酮 VMN损毁大鼠观察到的反馈由VMN的输入所介导 从杏仁核-海马区腹侧的细胞群和VMN是否 对食物摄入量和HPA轴活性的调节由 臂旁外侧核的缩胆囊素。

The purpose of these experiments is to understand how the ventromedial nuclei (VMN) direct neural and hormonal metabolic signals that may play a role in the development of clinical hypertension, obesity, and diabetes. Recent work from our lab has shown that the regulation of hypothalamic- pituitary-adrenal (HPA) axis function is embedded in a larger hypothalamic system regulates energy balance. The VMN of the hypothalamus are integral to feeding behavior, body weight, adrenocortical activity, and insulin secretion. We propose to study the integrative role VMN have on the HPA axis, feeding, and insulin secretion; we will test the hypothesis that inputs to the VMN from limbic and visceral inputs are involved. First, we will survey VMN's contribution to corticosteroid feedback on HPA function. Second, we will measure the degree to which circadian rhythms in HPA activity, and the effects of fasting on these rhythms, are mediated by VMN- driven input to the hypothalamic paraventricular nuclei (PVN) which contain the neuroendocrine motor output to the HPA axis. Finally, we will try to determine if the mineralocorticoid-receptor directed corticosterone feedback observed in rats with VMN lesions is mediated by inputs to VMN from cell groups in the ventral amygdalo-hippocampal area and whether VMN activity on food intake and HPA axis activity is regulated by cholecystokinin from the lateral parabrachial nuclei.