DIRECT INTERFACING WITH THE HUMAN CENTRAL NERVOUS SYSTEM

描述：我们建议在脑部植入长期记录电极。 瘫痪和哑巴认知完好无损的人的自愿皮质 (被锁定)试图连接他们的中枢神经系统 直接发送到通过语音合成器输出的文字处理机。我们 期望通过以下方式显著提高他们的日常生活能力 提供了另一种交流方式。 全球有500,000名被锁定的患者最终将失去 所有的交流方式。这些患者患有肌萎缩侧索硬化(Lou Gehrig‘s 疾病)、脑干中风和其他疾病。猴子和大鼠的数据 已经展示了一种可能的替代通信方式 被锁患者：使用神经营养电极，猴子提供了 区域个体动作电位长期记录的证据 4运动皮质。这些神经元处于自愿控制之下，可能也是如此 用于驱动通信设备。 手术时，患者应能控制关节的位置。 计算机屏幕上包含图标的光标(在Windows模式下)。三分之一 Signal将激活所需的图标，例如文字处理程序。 因此，被锁定的患者将直接从他/她的中心连接 神经系统连接到外部世界，从而绕过了神经的损伤。 建议的商业应用：不可用

DESCRIPTION: We propose to implant long-term recording electrodes in the voluntary cortex of cognitively intact humans who are paralyzed and mute ("locked-in") in an attempt to connect their central nervous systems directly to word processors outputted through speech synthesizers. We expect to thus markedly enhance their activities of daily living by providing an alternative means of communication. There are 500,000 "locked-in" patients worldwide who will eventually lose all means of communication. These patients suffer from ALS (Lou Gehrig's disease), brainstem strokes and other disorders. Data in monkeys and rats have demonstrated a possible alternative means of communication for locked-in patients: Using neurotrophic electrodes, monkeys have provided evidence of long-term recordings of individual action potentials in area 4 motor cortex. These neurons are under voluntary control and so might be used to drive communication devices. When operational, the patients should be able to control the position of a cursor on a computer screen containing icons (in Windows mode). A third signal will activate the desired icon such as a word processing program. Thus, the locked-in patient will connect directly from his/her central nervous system to the external world, thus bypassing the neural damage. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE