Implant Design and Development for Human Cortical Recording

在大脑皮层控制信号采集领域，记录系统是一个关键的瓶颈 将内部信号传递给外部应用程序。在这一领域中，人们一致认为存在皮质控制 可以用来控制假肢设备和恢复瘫痪肢体运动的信号，但这些 信号必须被快速完整地记录和传输。我们的目标是完成一项 无线、可扩展的128声道录音系统，适合人类长期使用。应用范围包括 闭锁病人的通讯，残疾人的环境控制，残疾人的运动恢复 脊髓损伤人群。 利用最近完成的两项第一阶段拨款，神经信号公司拥有满足这一要求的必要经验 进球。第一阶段工作(1 R43 NS-42478-01)设计并制造了8通道、灵活的表面贴装 组件，包括一个无线感应电源、内部校准、八个记录放大器和 八个FM发射机。在这次赠款期间开发的混合电路导致了四倍的 录音系统的音量，与我们以前的植入式录音系统相比。第二阶段I GRANT(1 R43 NS048706-01)刚刚完成。在这次资助期间，一个16通道集成电路(1C) 被制造成放大来自皮质电极的信号，并使用模拟扫描仪对信号进行多路传输。 第二阶段的具体目标是： A：继续开发集成电路器件，(1)结合电压调节和偏置 电路集成到集成电路中，以尽量减少外部半导体元件；(2)通过改进 基于在第一阶段开发中获得的知识的浮栅记录放大器和扫描仪； (3)继续开发(A)电力感应系统和(B)独特的同步扫描仪 将取代目前的调频系统的传输系统。 B：将神经营养电极连接小型化，以便与1C设备可靠连接。 C：选择和实施新的涂层，并对植入物进行浸泡测试和压力测试 录音装置，由录音放大器、电源、无线信号传输和 附接的电极。

In the field of cortical control signal acquisition, the recording system is a critical bottleneck for the passage of internal signals to external applications. It is agreed in this field that there are cortical control signals that can be used to control prosthetic devices and restore movement to paralyzed limbs, but these signals must be recorded and transmitted rapidly and intact. It is our goal to complete the development of a wireless, scalable 128-channel recording system, suitable for long-term human use. Applications range from communication for locked-in patients, to environmental control for the disabled, to motion restoration for the spinal cord injury population. Using two recently completed Phase I grants, Neural Signals has the necessary experience to meet this goal. The first Phase I effort (1 R43 NS-42478-01) designed and built an 8-channel, flexible, surface mount assembly, including a wireless inductive power supply, internal calibration, eight recording amplifiers, and eight FMtransmitters. The hybrid circuit developed during this grant resulted in a four-fold reduction in the recording system'svolume, compared to our previous implantable recording system. The second Phase I grant (1 R43 NS048706-01) has just been completed. During this grant, a 16-channel integrated circuit(1C) was fabricated to amplify signals from cortical electrodes and multiplex the signals using an analog scanner. Specific aims in Phase II are: A: Continue development of the integrated circuit device, (1) by incorporating voltage regulation and bias circuitry into the integrated circuit to minimize external semiconductor components; (2) by improving the floating gate recording amplifier and scanner based on knowledge gained during the Phase I development; (3) by continuing to develop (a) the power induction systemand (b) a unique synchronous scanner transmission system that will replace the present FM system. B: Miniaturize the Neurotrophic Electrode connections for reliable connection with the 1C device. C: Choose and implement new coatings and perform soak testing and stress testing of the implantable recording device consisting of the recording amplifiers, power supply, wireless signal transmission and attached electrodes.