Implant Design and Development for Human Cortical Recording

在大脑皮层控制信号的采集领域，记录系统是实现脑皮层控制信号采集的关键瓶颈。 将内部信号传递到外部应用程序。在这一领域，人们一致认为， 这些信号可用于控制假肢设备和恢复瘫痪肢体的运动，但这些 信号必须被记录并迅速和完整地传输。我们的目标是完成一个 无线、可扩展的128通道记录系统，适合人类长期使用。应用范围从 用于锁定患者的通信，用于残疾人的环境控制，用于 脊髓损伤人群。 使用两个最近完成的第一阶段赠款，神经信号有必要的经验，以满足这一点 目标.第一阶段的工作（1 R43 NS-42478-01）设计并构建了一个8通道、灵活的表面贴装 组件，包括无线感应电源，内部校准，八个记录放大器，以及 八个调频发射器在此期间开发的混合电路导致了四倍的减少， 记录系统的音量，与我们以前的植入式记录系统相比。第二阶段I 补助金（1 R43 NS 048706 -01）刚刚完成。在此期间，一个16通道集成电路（1C） 用于放大来自皮层电极的信号，并使用模拟扫描仪对信号进行多路复用。 第二阶段的具体目标是： A：继续开发集成电路器件，（1）通过整合电压调节和偏置 （2）通过改进集成电路中的电路，以最小化外部半导体组件; 浮栅记录放大器和扫描器的基础上获得的知识，在第一阶段的发展; (3)通过继续开发（a）电力感应系统和（B）独特的同步扫描器， 这将取代目前的FM系统。 B：微型化神经营养电极连接，以便与1C器械可靠连接。 C：选择并采用新涂层，并对植入式器械进行浸泡测试和应力测试 记录装置由记录放大器、电源、无线信号传输和 连接电极。

In the field of cortical control signal acquisition, the recording system is a critical bottleneck for the passage of internal signals to external applications. It is agreed in this field that there are cortical control signals that can be used to control prosthetic devices and restore movement to paralyzed limbs, but these signals must be recorded and transmitted rapidly and intact. It is our goal to complete the development of a wireless, scalable 128-channel recording system, suitable for long-term human use. Applications range from communication for locked-in patients, to environmental control for the disabled, to motion restoration for the spinal cord injury population. Using two recently completed Phase I grants, Neural Signals has the necessary experience to meet this goal. The first Phase I effort (1 R43 NS-42478-01) designed and built an 8-channel, flexible, surface mount assembly, including a wireless inductive power supply, internal calibration, eight recording amplifiers, and eight FMtransmitters. The hybrid circuit developed during this grant resulted in a four-fold reduction in the recording system'svolume, compared to our previous implantable recording system. The second Phase I grant (1 R43 NS048706-01) has just been completed. During this grant, a 16-channel integrated circuit(1C) was fabricated to amplify signals from cortical electrodes and multiplex the signals using an analog scanner. Specific aims in Phase II are: A: Continue development of the integrated circuit device, (1) by incorporating voltage regulation and bias circuitry into the integrated circuit to minimize external semiconductor components; (2) by improving the floating gate recording amplifier and scanner based on knowledge gained during the Phase I development; (3) by continuing to develop (a) the power induction systemand (b) a unique synchronous scanner transmission system that will replace the present FM system. B: Miniaturize the Neurotrophic Electrode connections for reliable connection with the 1C device. C: Choose and implement new coatings and perform soak testing and stress testing of the implantable recording device consisting of the recording amplifiers, power supply, wireless signal transmission and attached electrodes.