Polyimide Neurotrophic Electrode Development: Fabrication and Testing

描述（由申请人提供）：拟定工作旨在进一步开发用于长期侵入性皮质记录的聚酰亚胺神经营养电极。最初的神经营养电极是专门为长期记录而设计的，通过营养因子促进神经突生长到玻璃记录锥中。使用标准微电子制造技术可以进一步最小化和控制电极设计。将通过测量电气特性（包括阻抗和功率谱密度）和长期浸泡试验对制造的电极进行评价。公共卫生相关性：长期皮层记录电极的发展是脑机接口（BCI）进一步发展的必要条件。脑机接口有可能减轻由ALS（Lou Gehrig病）或下脑干中风引起的闭锁综合征受试者的痛苦。

DESCRIPTION (provided by applicant): The proposed work seeks to further development of a polyimide-based Neurotrophic Electrode for long term invasive cortical recordings. The original Neurotrophic Electrode was specifically designed for long term recordings by encouraging neurite growth into a glass recording cone by trophic factors. The electrode design can be further minimized and controlled using standard microelectonic fabrication techniques. The fabricated electrodes will be evaluated by measuring the electrical characteristics, including impedance and power spectral density, and through long term soak tests. PUBLIC HEALTH RELEVANCE: The development of electrodes for long term cortical recordings is essential to further progress of Brain Computer Interfaces (BCIs). BCIs have the potential to alleviate the suffering of subjects with locked-in syndrome caused by ALS (Lou Gehrig's disease) or lower brain stem stroke.