Polyimide Neurotrophic Electrode Development: Fabrication and Testing

描述(由申请人提供)：建议的工作旨在进一步开发一种基于聚酰亚胺的神经营养电极，用于长期的侵入性皮质记录。最初的神经营养电极是专门为长期记录而设计的，通过营养因子鼓励轴突生长到玻璃记录锥体中。使用标准的微电子制造技术可以进一步最小化和控制电极设计。制作的电极将通过测量包括阻抗和功率谱密度在内的电特性以及通过长期浸泡试验进行评估。公共卫生相关性：用于长期皮质记录的电极的开发对于脑计算机接口(BCI)的进一步发展至关重要。BCI有可能减轻由肌萎缩侧索硬化症(卢·格里克病)或低位脑干中风引起的闭锁综合征患者的痛苦。

DESCRIPTION (provided by applicant): The proposed work seeks to further development of a polyimide-based Neurotrophic Electrode for long term invasive cortical recordings. The original Neurotrophic Electrode was specifically designed for long term recordings by encouraging neurite growth into a glass recording cone by trophic factors. The electrode design can be further minimized and controlled using standard microelectonic fabrication techniques. The fabricated electrodes will be evaluated by measuring the electrical characteristics, including impedance and power spectral density, and through long term soak tests. PUBLIC HEALTH RELEVANCE: The development of electrodes for long term cortical recordings is essential to further progress of Brain Computer Interfaces (BCIs). BCIs have the potential to alleviate the suffering of subjects with locked-in syndrome caused by ALS (Lou Gehrig's disease) or lower brain stem stroke.