IC Design and Development for Human Brain Implantations

描述(申请人提供)：在神经假体领域，需要多通道记录系统，该系统可植入头皮下，可从植入人体皮质的多个电极进行记录。这些系统必须具有寿命长、可靠性高和高带宽才能记录尖锐的瞬时神经活动。我们在这项建议中的目标是在我们经验的基础上建立2通道系统，这是最近开发的8通道系统，并将其提升到128通道系统的下一个级别，所有这些都占用相同的小空间。我们的具体目标是(A)设计用于记录生物信号的高密度集成电路放大器，(B)设计多路复用系统，以及(C)在MOSIS铸造厂和台架测试中制造集成电路。较长期的目标是(I)将IC和MUX整合到我们最近完成的混合植入式电子设备中，保留功率感应模块、校准信号和调频发射器的使用。我们还将开发一种多路分解器。(Ii)改进电力感应线圈，使其可在距离受试者头部或含有电力感应接收线圈的身体部分一段距离内使用。这也将包括开发一种功率放大器，如E型放大器。(Iii)将该IC并入基于LCP的封装或其他基板和互连技术。(Iv)在广泛的试验台测试后，将这些装置植入猴子体内，为人类和动物植入做准备。 我们希望这一努力最终将产生一种记录系统，该系统将成为人类神经假体植入的标准，从而为减轻人类的痛苦和残疾做出重大贡献。

DESCRIPTION (provided by applicant): In the field of Neural Prostheses, there is a need for multi-channel recording systems that are implantable under the scalp and that can record from multiple electrodes implanted in human cortex. These systems must have longevity, reliability and high bandwith for recording sharp transient neural activity. Our aim in this proposal is to build on our experience with a 2 channel system, a recently developed eight channel system, and take this to the next level of a 128 channel system, all on the same small footprint. Our specific aims are to (a) design high-density integrated circuit amplifiers for recording biological signals, (b) design a multiplexing system, and (c) fabricate the integrated circuit in the MOSIS foundry and bench test. Longer-term aims are to (i) Incorporate the IC and MUX into our recently completed Hybrid Implantable Electronic Device retaining use of the power induction module, calibration signal and FM transmitters. We would also develop a demultiplexer. (ii) Improve the power induction coil so that it can be used at a distance from the subjects' head or body part containing the power induction receiver coil. This will also involve development of a power amplifier such as an E type amplifier. (iii) Incorporate this IC into LCP based packaging or other substrate and inter-connect technology. (iv) Implant these devices into monkeys after extensive bench testing in preparation for human as well as animal implantation. We expect this effort to eventually result in a recording system that will be the standard for human neural prostheses implantations, thus contributing significantly to the alleviation of human suffering and disability.