BIOPSY NEEDLE FOR TUMOR BLOOD FLOW QUANTIFICATION

用于肿瘤血流定量的活检针

• 批准号: 2715930
• 负责人: GREGORY T MARTIN
• 金额: $ 10万
• 依托单位: THERMAL TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 1999-03-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2715930
• 关键词: bioengineering /biomedical engineering; biomedical equipment development; biopsy; biosensor device; blood circulation; blood flow measurement; clinical biomedical equipment; computer program /software; computer simulation; fine needle aspiration; heat; human therapy evaluation; laboratory rat; mathematical model; neoplasm /cancer blood supply; neoplasm /cancer therapy; phantom model; temperature; thermometry

This project seeks to incorporate blood flow (perfusion) sensors with core and aspiration biopsy needles. This device (needle, sensor, instrument and software) will serve as a research tool to investigate the relationship between tumor blood flow/oxygenation and anti-tumor therapy outcome. Since perfusion is a primary mediator of tissue oxygenation, and since oxygen acts as a modifier of the effectiveness of radiation therapy and chemotherapeutic agents, perfusion plays a role in the outcome of these therapies. During hyperthermia, higher therapeutic temperatures are achieved when tumor flow is low. Currently, there does not exist a tool to conveniently and routinely assess tumor perfusion in conjunction with anti-cancer therapy. In a research setting, the proposed device will help determine if such a perfusion/therapy outcome relationship exists. In clinical oncology, this device will provide information to assess the success of tumor blood flow modification agents, to help plan anti-tumor therapy for mammal effectiveness and to unambiguously ensure that the biopsy is taken from viable, non-necrotic tissue. This low cost device will also allow the perfusion data to be collected without increased patient morbidity nor increased risk for seeding the normal surrounding tissue with tumor cells over that of a standard biopsy procedure. The ability of the sensor to detect significantly sized vessel within1-2mm may also help navigate the biopsy needle through tissue to avoid these vessels in the biopsy path. Future versions of this device may incorporate other physiologic sensors relevant to clinical interest. PROPOSED COMMERCIAL APPLICATION: The proposed instrumented biopsy needle for the measurement of tumor blood flow has the potential to predict the efficacy of non-surgical anti-tumor therapy for hundreds of thousands of patients in the US each year. This device should find wide application in many research centers studying tumor blood flow in animal models and humans. A low-cost biopsy needle adjunct which quantifies tissue viability and tissue ischemia, and permits sensing of vessels in close proximity to the needle tip to aid in navigation, is expected to have great commercial potential.

该项目旨在将血流（灌注）传感器与 核心和抽吸活检针。 该装置（针、传感器， 仪器和软件）将作为研究工具， 肿瘤血流/氧合与抗肿瘤关系 治疗结果 由于灌注是组织的主要介质， 氧合，并且由于氧充当有效性的改性剂， 在放射治疗和化疗药物中，灌注起作用， 这些治疗的结果。 在高温期间， 当肿瘤流量低时达到治疗温度。 目前，不存在一种工具来方便地和常规地 结合抗癌治疗评估肿瘤灌注。 中 研究设置，拟议的设备将有助于确定这样的 存在灌注/治疗结果关系。 在临床肿瘤学中， 该设备将提供信息以评估肿瘤治疗的成功率。 血流调节剂，以帮助计划抗肿瘤治疗， 哺乳动物的有效性，并明确确保活检是 取自活的非坏死组织。 这种低成本的设备还将 允许在不增加患者数量的情况下收集灌注数据， 发病率也没有增加接种正常周围组织的风险 肿瘤细胞的数量超过了标准活检程序。 的能力 用于检测1 - 2 mm内的显著尺寸血管的传感器还可以 帮助引导活检针穿过组织以避开这些血管 该装置的未来版本可能包括 与临床相关的其他生理传感器。 拟定商业应用： 用于测量肿瘤的仪器化活检针 血流量有可能预测非手术治疗的疗效 在美国， 年 这种装置在许多研究中心应该得到广泛的应用 研究动物模型和人类的肿瘤血流。 一种低成本 活检针附件，其量化组织活力和组织 局部缺血，并允许感测靠近缺血的血管。 针尖，以帮助导航，预计将有很大的商业 潜力