Real-time Cerebral Blood Flow Monitoring System

实时脑血流监测系统

• 批准号: 6737203
• 负责人: GREGORY T MARTIN
• 金额: $ 33.66万
• 依托单位: THERMAL TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-06-01 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6737203
• 关键词: aneurysm; biomedical equipment development; brain circulation; catheterization; cerebrospinal fluid; clinical research; computer human interaction; computer program /software; computer system design /evaluation; computer system hardware; hemorrhage; human subject; intracranial pressure; patient monitoring device; patient oriented research; subarachnoid space; time resolved data

DESCRIPTION (provided by applicant): The objective of this project is to develop a minimally invasive and multimodal neurosurgical monitoring system that is capable of simultaneously measuring cerebral blood flow (CBF) and intracranial pressure (ICP) continuously and in real time. This innovative approach will combine the measurement modalities with the ability to drain cerebrospinal fluid (CSF) to control ICP with the same device. Each year in the U.S. there are 370,000 incidents of traumatic brain injury (TBI) and 100,000 subsequent deaths. Injury results from a primary trauma and a later secondary injury caused by local ishemia (deficient blood supply) in viable tissue. Monitoring and interventional therapies to prevent secondary injury attempt to maintain an adequate level of CBF to viable tissue by controlling ICP below a threshold level. While in practice CBF is not typically monitored, ICP is used to indirectly assess ischemic risk. Direct, real-time and continuous monitoring of CBF will help guide therapy, provide an early warning for ischemia, vasospasm, and neurophysiologic deterioration, allow customization of patient-specific therapy and help understand neurophysiology. For the neurosurgeon, the measurement of CBF at the bedside has been long desired and sought after. In Phase II, the multimodal minimally invasive and instrumented ventricular catheter will be designed and developed. Also, the multimodal monitor and associated software will be developed and utilized in a series of studies with head-injured patients. Custom intracranial access hardware will be developed to facilitate the introduction the catheter into cerebral tissue. The monitor will have a color LCD display and an intuitive user interface. CBF and ICP will be displayed in numerical and graphical form continuously and in real time. A series of clinical studies will be performed to monitor CBF in patients with traumatic injury or aneurismal subarachnoid hemorrhage. The aim of this study is to confirm the high level of clinical value CBF and ICP monitoring has as an early warning of clinically relevant events.

描述(申请人提供)：本项目的目标是开发一种微创和多模式的神经外科监护系统，能够同时连续和实时地测量脑血流量(CBF)和颅内压(ICP)。这一创新的方法将把测量方式与排出脑脊液(CSF)的能力结合起来，以使用相同的设备控制颅内压。在美国，每年有37万起创伤性脑损伤(TBI)事件和10万人随后死亡。损伤是由原发创伤和后来的二次损伤造成的，后者是由于存活组织中的局部缺血(血液供应不足)造成的。监测和介入治疗以防止二次损伤，试图通过控制颅内压低于阈值水平来维持对存活组织足够的CBF水平。虽然在实践中通常不监测脑血流量，但可以使用颅内压间接评估缺血风险。对CBF的直接、实时和持续监测将有助于指导治疗，为缺血、血管痉挛和神经生理学恶化提供早期预警，允许定制针对患者的治疗方案，并有助于了解神经生理学。对于神经外科医生来说，床边的CBF测量一直是人们渴望和追逐的目标。 在第二阶段，将设计和开发多模式微创和仪器化的脑室导管。此外，还将开发多模式监护仪和相关软件，并将其用于对头部受伤患者的一系列研究。将开发定制的颅内通路硬件，以促进将导管引入脑组织。该显示器将配备彩色LCD显示屏和直观的用户界面。CBF和ICP将以数字和图形的形式连续和实时显示。将进行一系列临床研究，以监测创伤性损伤或动脉瘤性蛛网膜下腔出血患者的脑血流。这项研究的目的是确认CBF和颅内压监测作为临床相关事件的早期预警具有很高的临床价值。