NONINVASIVE PERFUSION MEASUREMENT SYSTEM

无创灌注测量系统

• 批准号: 2651515
• 负责人: GREGORY T MARTIN
• 金额: $ 10万
• 依托单位: THERMAL TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-05-01 至 1999-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2651515
• 关键词: biomedical equipment development; blood flow measurement; computer program /software; diagnosis design /evaluation; laboratory rat; microcapsule; monitoring device; noninvasive diagnosis; perfusion

This project develop a clinical monitoring system to quantify blood flow (perfusion) continuously, in real-time, using non-invasive senors. Perfusion quantification is now effectively unavailable, yet insuring adequate tissue blood flow is universally acknowledged as being essential to many medical procedures. Examples include reconstructive surgery, organ transplantation, vessel grafting, bypass procedures, and burn and wound healing, each of which depends on a viable vasculature. The perfusion monitoring system will ultimately comprise and array of multiple non-invasive surface sensors and translation electronics under control of a personal computer which also provides the user interface, data collection and management software. This Phase I project addresses the feasibility and optimal design of the non-invasive perfusion sensor. Prototype senors will be fabricated and evaluated, a thermal model of the sensor will be formulated to extract perfusion from raw power versus time data and preliminary validation studies will characterize sensor sensitivity, response and accuracy. In Phase II, the non-invasive sensor design will be replicated to a sensor array designed to provide a map of the tissue perfusion distribution. Applications will be to numerous medical procedures whose success depends on restoring and maintaining a viable tissue vasculature and to the identification of ischemic tissue leading to diagnosis and early options for management of treatment. PROPOSED COMMERCIAL APPLICATION Many of the 500,000 muscle and myocutaneous flap reconstructions, 12,000 kidney and 4,000 liver transplants performed in the US each year as well as other procedures whose success depends on restoring and maintaining a viable tissue vasculature could greatly benefit from this proposed device that will non-invasively quantify tissue perfusion continuously and in real-time. Current competing techniques to measure tissue flow are either extremely complex and performed only in the context of physiologic research or are too simplistic to yield useful information in terms of the flow level, variation, quantification and spatial distribution.

该项目开发了一种临床监测系统来量化血液流量。 (灌流)连续、实时地使用非侵入性传感器。 血流灌注定量现在实际上是不可用的，但可以确保 人们普遍认为，充足的组织血流是 对许多医疗程序来说都是必不可少的。例子包括重建 外科手术，器官移植，血管移植，搭桥手术，以及 烧伤和伤口愈合，每一项都依赖于可行的血管系统。 灌流监测系统最终将包括和阵列 多个非侵入式表面传感器和平移电子设备 控制也提供用户界面的个人计算机， 数据采集和管理软件。此第一阶段项目旨在 无创血流传感器的可行性及优化设计。 原型传感器将被制造和评估，一个热模型 传感器将被设计成从原始能量中提取灌流，而不是 时间数据和初步验证研究将描述传感器的特征 敏感度、响应度和准确性。在第二阶段，非侵入性 传感器设计将复制到传感器阵列，旨在提供 组织灌注量分布图。申请将提交给 无数的医疗程序的成功取决于恢复和 维持有活力的组织血管系统并鉴定 导致诊断的缺血组织和早期治疗选择 关于治疗的问题。 建议的商业应用 500,000个肌肉和肌皮瓣重建中的许多，12,000个 美国每年还进行4000例肾脏和肝脏移植 与其他成功依赖于恢复和维护的过程一样 一个有活力的组织血管系统将从这项提议中受益匪浅 一种可连续无创量化组织灌注量的装置 并且是实时的。目前相互竞争的测量组织流的技术 要么极其复杂，要么只在 生理学研究或过于简单化，无法提供有用的信息 从流量的水平、变化、量化和空间上看 分发。