Real-time Cerebral Blood Flow Monitoring System

实时脑血流监测系统

• 批准号: 6887813
• 负责人: GREGORY T MARTIN
• 金额: $ 33.36万
• 依托单位: THERMAL TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-06-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6887813
• 关键词: aneurysm; biomedical equipment development; brain circulation; catheterization; cerebrospinal fluid; clinical research; computer human interaction; computer program /software; computer system design /evaluation; computer system hardware; hemorrhage; human subject; intracranial pressure; patient monitoring device; patient oriented research; subarachnoid space; time resolved data

DESCRIPTION (provided by applicant): The objective of this project is to develop a minimally invasive and multimodal neurosurgical monitoring system that is capable of simultaneously measuring cerebral blood flow (CBF) and intracranial pressure (ICP) continuously and in real time. This innovative approach will combine the measurement modalities with the ability to drain cerebrospinal fluid (CSF) to control ICP with the same device. Each year in the U.S. there are 370,000 incidents of traumatic brain injury (TBI) and 100,000 subsequent deaths. Injury results from a primary trauma and a later secondary injury caused by local ishemia (deficient blood supply) in viable tissue. Monitoring and interventional therapies to prevent secondary injury attempt to maintain an adequate level of CBF to viable tissue by controlling ICP below a threshold level. While in practice CBF is not typically monitored, ICP is used to indirectly assess ischemic risk. Direct, real-time and continuous monitoring of CBF will help guide therapy, provide an early warning for ischemia, vasospasm, and neurophysiologic deterioration, allow customization of patient-specific therapy and help understand neurophysiology. For the neurosurgeon, the measurement of CBF at the bedside has been long desired and sought after. In Phase II, the multimodal minimally invasive and instrumented ventricular catheter will be designed and developed. Also, the multimodal monitor and associated software will be developed and utilized in a series of studies with head-injured patients. Custom intracranial access hardware will be developed to facilitate the introduction the catheter into cerebral tissue. The monitor will have a color LCD display and an intuitive user interface. CBF and ICP will be displayed in numerical and graphical form continuously and in real time. A series of clinical studies will be performed to monitor CBF in patients with traumatic injury or aneurismal subarachnoid hemorrhage. The aim of this study is to confirm the high level of clinical value CBF and ICP monitoring has as an early warning of clinically relevant events.

描述（由申请人提供）：该项目的目标是开发一种能够同时连续实时测量脑血流量（CBF）和颅内压（ICP）的微创多模式神经外科监测系统。这种创新的方法将把测量方式与排出脑脊液（CSF）的能力结合起来，用同一装置控制ICP。美国每年有37万起创伤性脑损伤（TBI）事件，随后有10万人死亡。损伤是由原发性创伤和后来由活组织局部缺血（血液供应不足）引起的继发性损伤引起的。监测和介入治疗以防止继发性损伤，试图通过控制ICP低于阈值水平来维持活组织的足够CBF水平。虽然在实践中通常不监测脑血流，但ICP用于间接评估缺血性风险。直接、实时和连续监测脑血流将有助于指导治疗，为缺血、血管痉挛和神经生理恶化提供早期预警，允许定制患者特异性治疗，并有助于了解神经生理学。对于神经外科医生来说，在床边测量脑血流一直是他们梦寐以求的。