ULTRA UNIFORM TEMPERATURE PCR THERMAL CYCLER

超均温 PCR 热循环仪

• 批准号: 2644201
• 负责人: JIM HANG
• 金额: $ 10.94万
• 依托单位: NEW DIMENSION RESEARCH & INSTRUMENT
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-05-15 至 1999-05-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2644201
• 关键词: biomedical equipment development; cold temperature; heat; polymerase chain reaction; temperature

DESCRIPTION (Adapted from investigator's abstract): The principal goal of the project is to demonstrate the feasibility of developing, and eventually bringing to market, an innovative ultra-uniform temperature, fast-temperature-response 96 well thermal block for polymerase chain reaction (PCR) thermal cyclers. They propose to use a proprietary material (TPG graphite) of very high thermal conductivity, embedded in the thermal block. They propose to demonstrate that temperature variation across our thermal block will be less than 0.1 degrees C, at 94 degrees C, while in the conventional one it will be at least 1 degree C. Since the thermal block has such high thermal conductivity, they expect that temperature response will be much faster than in any existing heating thermal block. Another goal of this project is to explore the feasibility of making a portable, low cost, even battery-operated PCR thermal cycler. Because of the high thermal conductivity of the new material, thermal energies will be easy to put in and take out from the thermal block and the Peltier. Size of both the heat sink and power source can be reduced dramatically. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE

描述（改编自研究者摘要）：主要目标 项目的目的是论证开发的可行性， 最终将创新的超均匀温度推向市场， 聚合酶链快速温度响应96孔热阻断 反应（PCR）热循环仪。 他们建议使用一种专有的 导热性非常高的材料（TPG石墨），嵌入在 热块。 他们提出要证明温度 整个热块的变化将小于0.1摄氏度， 94摄氏度，而在传统的一个，这将是至少1度 C.由于热块具有如此高的导热性， 预计温度响应将比任何 现有的加热热块。 本项目的另一个目标是探索在全球范围内 便携式、低成本、甚至电池供电的PCR热循环仪。 因为 新材料的高导热性， 将很容易放入和取出从热块和 佩尔蒂埃 可以减小散热器和电源的尺寸 戏剧性地。 拟议商业应用：不可用