CONFOCAL SCANNING MICRO-LASER/DETECTOR MICROSCOPE

共焦扫描微型激光/探测器显微镜

• 批准号: 2716974
• 负责人: JIM HANG
• 金额: $ 34.93万
• 依托单位: NEW DIMENSION RESEARCH & INSTRUMENT
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 2000-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2716974
• 关键词: bioengineering /biomedical engineering; biomedical equipment development; computer program /software; computer system design /evaluation; confocal scanning microscopy; cytology; digital imaging; image processing; lasers; semiconduction

New Dimension Research Inc. is developing an innovative portable confocal scanning laser microscope (PCSM) by using a matrix-addressable laser/detector array chip (MALD). Unlike conventional confocal laser scanning microscopes, this instrument has no moving parts or bulky optics. Its low cost, portability and fast image acquisition make it ideal for biological research, and for the diagnosis of cancers and other diseases requiring microscopy. There currently exists no fast-imaging instrumentation that is compact and readily deployable in clinical or research laboratories. This system provides a high efficient, high output for the real-time cell imaging. This capability is essential in order to reap the benefits of the ongoing biomedical revolution. Our objective is to further the development of the technology demonstrated in Phase I which produced confocal scanning imaging by using a two-dimensional micro-laser/detector array. Phase ll will also address the technical issues required for Phase III commercialization and production of the two-dimensional matrix-addressable laser/detector array with control circuits, bilens and accessory electronics. The goal of the Phase II is to demonstrate that confocal imaging can be obtained by using a matrix-addressable laser/detector array, and the optical-sectional imaging of the biological tissue, as well as to develop a prototype of a portable microscope. PROPOSED COMMERCIAL APPLICATIONS: We foresee that the applications of confocal microscopy can range from biomedical research to clinic diagnosis, from pharmaceutical to semiconductor manufactures.

新维度研究公司正在开发一种创新的便携式共焦 扫描激光显微镜（PCSM）通过使用矩阵寻址 激光器/探测器阵列芯片（MALD）。不同于传统的共焦激光器 扫描显微镜，该仪器没有移动部件或体积庞大 光学.它的低成本、便携性和快速图像采集使其 非常适合生物学研究，以及癌症和其他疾病的诊断 需要显微镜检查的疾病目前不存在快速成像 紧凑且易于在临床或手术中部署的器械 研究实验室。该系统提供了一个高效率，高产量 用于实时细胞成像。这一能力至关重要， 从生物医学革命中获益。 我们的目标是进一步发展这项技术 在第一阶段中证明了这一点， 二维微型激光器/探测器阵列。第二阶段还将解决 第三阶段商业化所需的技术问题， 二维矩阵可寻址激光器/探测器阵列的制作 带有控制电路、双镜头和附属电子设备。的目标 第二阶段是证明共焦成像可以通过使用 矩阵可寻址激光器/检测器阵列，以及光学部分 生物组织的成像，以及开发一个原型， 便携式显微镜 拟议的商业应用： 我们预见共聚焦显微镜的应用范围可以从 从生物医学研究到临床诊断，从制药到 半导体制造商。