A cellular hub for the organisation of T cell priming

组织 T 细胞启动的细胞中心

• 批准号: DP190103691
• 负责人: Prof Scott Mueller
• 金额: $ 40.72万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP190103691
• 关键词: cellular; hub; organisation; cell; priming

This project aims to delineate the cellular interactions involved in the initiation of immune responses by utilising advanced in vivo imaging. Adaptive immunity in vertebrates functions via the acquisition of signals by immune cells via complex interactions with other immune cells, yet these exchanges are difficult to observe and define. This project expects to provide insights into the mechanisms that underpin effective cell-mediated immune responses. The expected outcomes are to generate fundamental new knowledge about immune responses and enhance capacity to study the immune system. This could benefit future development of new vaccines and therapies to improve health.

该项目旨在通过利用先进的体内成像来描绘参与免疫应答启动的细胞相互作用。脊椎动物的适应性免疫功能是通过免疫细胞与其他免疫细胞的复杂相互作用来获取信号，但这些交换很难观察和定义。该项目预计将提供对支持有效细胞介导的免疫反应的机制的见解。预期的成果是产生关于免疫反应的基本新知识，并提高研究免疫系统的能力。这可能有利于未来开发新的疫苗和疗法，以改善健康状况。