Defining the immunological roles of stromal cells within lymphoid tissues

定义淋巴组织内基质细胞的免疫学作用

• 批准号: DP140101246
• 负责人: Prof Scott Mueller
• 金额: $ 31.64万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP140101246
• 关键词: Defining; immunological; roles; stromal; cells

The populations of endothelial and mesenchymal cells that construct the lymphoid tissues are being revealed as key players in the priming and orchestration of immune responses. Yet, fundamental knowledge of the molecular makeup and the functions of these stromal cells, particularly their roles in immune responses, is sorely lacking. This project will utilise a multidisciplinary approach including advanced imaging and bioinformatics to dissect the functions of the lymphoid stromal cells and their roles in the swelling of lymphoid tissues during immune responses. This will provide vital information about the biology of these understudied cells and reveal the ways in which they support the generation of immunity.

构成淋巴组织的内皮细胞和间充质细胞群体被揭示为免疫反应的启动和协调的关键角色。然而，对于这些基质细胞的分子组成和功能，特别是它们在免疫反应中的作用，基础知识严重缺乏。该项目将利用包括先进的成像和生物信息学在内的多学科方法来剖析淋巴基质细胞的功能及其在免疫反应期间淋巴组织肿胀中的作用。这将提供有关这些未被研究的细胞生物学的重要信息，并揭示它们支持免疫生成的方式。