Imaging the generation and recall of protective antiviral immune responses in vivo

体内保护性抗病毒免疫反应的产生和回忆的成像

• 批准号: FT130100197
• 负责人: Prof Scott Mueller
• 金额: $ 52.51万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT130100197
• 关键词: Imaging; generation; recall; protective; antiviral

Our understanding of the in vivo dynamics of cellular immune responses to infectious diseases is poor. This project will utilise advanced intravital imaging combined with novel tools to dissect the cellular events involved in the generation and recall of T cell responses to localised virus infection, combined with a detailed functional analysis of the lymphoid organ stroma. Such fundamental information will contribute to the development of new generation vaccines and therapies to protect against tissue-specific infectious diseases, cancers and autoimmune diseases.

我们对传染病细胞免疫反应的体内动力学了解甚少。该项目将利用先进的活体成像与新颖的工具相结合，剖析涉及 T 细胞对局部病毒感染反应的生成和回忆的细胞事件，并结合淋巴器官基质的详细功能分析。这些基本信息将有助于开发新一代疫苗和疗法，以预防组织特异性传染病、癌症和自身免疫性疾病。