SOLUBLE AND ANTIGENIC PHOSPHOINOSITIDE PHOSPHATES

描述(改编自申请)：肌醇磷脂 多聚磷酸盐(PIPns)是细胞内的关键信号分子 通过蛋白激酶，在内吞和胞吐，以及在 蛋白质的囊泡运输。PIPN由一个七口之家组成 基于磷酸盐的数量和位置的分子支架 肌醇头部组。大多数PIPN只能按总化学物质计算 合成，需要全球200多个实验室的生物学家找到并 学术合作者。不同品种的PIPN的数量需求 二酰甘油链现在已经超过了这些实验室的能力。可用性 这些信号分子和检测它们的试剂将 促进过敏、炎症、细胞凋亡、癌症和 神经系统疾病。梯队研究实验室(ERL)是一个三级 商业战略。首先，ERL将开发四个PIPn合成 不同甘油二酯衍生物分子支架的制备 PIPn衍生物的“匹配组”，包括短链、中间体 链，并将“可系留”类比功能化。他们将使用 功能化PIPns制备抗原型PIPns用于诱导 PIPn特异性抗血清。其次，他们将开发酶试剂盒 和结合蛋白分析。第三，他们将使用这些试剂和化验 药物发现中的方法。 建议的商业应用： 潜在的商业应用程序不可用。

DESCRIPTION (Adapted from the application): Phosphoinositide polyphosphates (PIPns) are key signaling molecules in cellular communication via protein kinases, in endo- and exocytosis, and in vesicular trafficking of proteins. The PIPns consist of a family of seven molecular scaffolds based on the number and position of phosphates on the inositol head group. Most PIPns are available only by total chemical synthesis, requiring that biologists in over 200 labs worldwide locate and academic collaborator. The demand of quantities of PIPns with a variety of diacylglyceryl chains now exceeds the capacity of these labs. Availability of these signaling molecules and reagents for their detection will facilitate drug discovery in allergy, inflammation, apoptosis, cancer and neurological diseases. Echelon Research Laboratories (ERL) is a three-tier business strategy. First, ERL will develop PIPn synthesis for four different diacylglycerol derivatives of molecular scaffolds to make "matched sets" of PIPn derivatives, including short-chain, intermediate chain, and functionalize "tetherable" analogs. They will use functionalized PIPns to prepare antigenic forms of the PIPns for eliciting PIPn-specific antisera. Second, they will develop reagent kits for enzyme and binding protein assays. Third, they will use these reagents and assay methods in drug discovery. PROPOSED COMMERCIAL APPLICATION: Potential commercial application not available.