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SOLUBLE AND ANTIGENIC PHOSPHOINOSITIDE PHOSPHATES

可溶性和抗原性磷酸肌醇磷酸盐

基本信息

批准号：
2643516
负责人：
GLENN DOWNES PRESTWICH
金额：
$ 9.18万
依托单位：
ECHELON BIOSCIENCES, INC.
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
起止时间：
1998-05-01 至 1999-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/2643516
关键词：
chemical synthesis method development phosphatidate phosphatase phosphatidylinositols

项目摘要

DESCRIPTION (Adapted from the application): Phosphoinositide polyphosphates (PIPns) are key signaling molecules in cellular communication via protein kinases, in endo- and exocytosis, and in vesicular trafficking of proteins. The PIPns consist of a family of seven molecular scaffolds based on the number and position of phosphates on the inositol head group. Most PIPns are available only by total chemical synthesis, requiring that biologists in over 200 labs worldwide locate and academic collaborator. The demand of quantities of PIPns with a variety of diacylglyceryl chains now exceeds the capacity of these labs. Availability of these signaling molecules and reagents for their detection will facilitate drug discovery in allergy, inflammation, apoptosis, cancer and neurological diseases. Echelon Research Laboratories (ERL) is a three-tier business strategy. First, ERL will develop PIPn synthesis for four different diacylglycerol derivatives of molecular scaffolds to make "matched sets" of PIPn derivatives, including short-chain, intermediate chain, and functionalize "tetherable" analogs. They will use functionalized PIPns to prepare antigenic forms of the PIPns for eliciting PIPn-specific antisera. Second, they will develop reagent kits for enzyme and binding protein assays. Third, they will use these reagents and assay methods in drug discovery. PROPOSED COMMERCIAL APPLICATION: Potential commercial application not available.

描述（改编自申请）：磷酸肌醇多磷酸盐（PIPns）是细胞内的关键信号分子，通过蛋白激酶，在胞内和胞吐，以及在蛋白质的囊泡运输。PIPns一家七口基于磷酸盐的数量和位置的分子支架肌醇头基。大多数PIPn仅可通过全化学品获得合成，需要生物学家在全球200多个实验室定位，学术合作者。对具有多种性能的PIPns的需求量二酰基甘油链现在超过了这些实验室的能力。可用性这些信号分子和用于检测它们的试剂将促进过敏症、炎症、细胞凋亡、癌症和神经系统疾病Echelon研究实验室（ERL）是一个三层商业战略。首先，ERL将开发四个PIPn合成不同的甘油二酯衍生物的分子支架， PIPn衍生物的“匹配组”，包括短链、中间体、链，并官能化“可栓系”类似物。他们将使用功能化的PIPn，以制备PIPn的抗原形式，用于引发 PIP n特异性抗血清。其次，他们将开发酶的试剂盒和结合蛋白测定。第三，他们将使用这些试剂和分析药物发现的方法。拟定商业应用：潜在的商业应用不可用。