Mechanistic Studies and Method Development in Asymmetric Organocatalysis

不对称有机催化的机理研究和方法开发

基本信息

  • 批准号:
    RGPIN-2022-04499
  • 负责人:
  • 金额:
    $ 2.11万
  • 依托单位:
  • 依托单位国家:
    加拿大
  • 项目类别:
    Discovery Grants Program - Individual
  • 财政年份:
    2022
  • 资助国家:
    加拿大
  • 起止时间:
    2022-01-01 至 2023-12-31
  • 项目状态:
    已结题

项目摘要

Chiral compounds, which exist as a pair of non-superimposable mirror images (called enantiomers), are the building blocks of all life. Living organisms are comprised of chiral molecules and are therefore sensitive to the chirality of the compounds with which they interact. As a result, chiral compounds are widely used in the manufacturing of pharmaceuticals, agrochemicals, fragrances, flavourings, cosmetics and fine chemicals. The global Chiral Chemicals market was valued at $53,930 million USD in 2020 and is expected to reach $101,350 million USD by the end of 2027, according to the Global Industry Research Report. It is well established that the different enantiomers of a compound can have vastly different biological activities. Many of the chiral compounds produced industrially are required in an enantiomerically pure form (only one of the two enantiomers), as regulatory agencies have recognized that each enantiomer of a compound can have different effects when interacting with biological systems, including the human body. It is an ongoing and pressing challenge to develop robust and reliable processes that produce a single enantiomer of a compound to satisfy the demand for enantiopure chiral chemicals. Asymmetric organocatalysis has emerged as a powerful synthetic methodology that has provided access to a variety of previously unachievable enantioselective transformations, resulting in a diverse array of enantioenriched chiral compounds. Asymmetric organocatalysis employs chiral organic molecules, largely derived from amino acids, to activate another molecule and promote the formation of new bonds in a stereoselective manner. The impact of this work has led to its global recognition as a key synthetic methodology and the awarding of the 2021 Nobel Prize to the founders of the field. The Davis group is working at the forefronts of organocatalysis to develop new catalysts and reactions that will expand the types of enantioselective reactions that can be performed and increase the number of chiral molecules that can be created with this catalytic method. We are focused on addressing standing issues in the field including the development of catalysts that promote photochemical reactions and the installation of new bonds further from the catalyst. We will then apply these methods in the synthesis of biologically significant compounds, demonstrating the strength of these catalytic methods in converting cheap achiral starting materials into high value, industrially relevant enantioenriched chiral compounds. This work will generate catalytic methods that will aid in addressing the current needs of the chiral chemical industry and will produce researchers that are uniquely trained to address the future challenges facing this rapidly growing area of the economy.
手性化合物,以一对不可重叠的镜像(称为对映体)的形式存在,是所有生命的基石。生物体由手性分子组成,因此对与它们相互作用的化合物的手性敏感。因此,手性化合物广泛用于制造药物、农用化学品、香料、调味品、化妆品和精细化学品。根据全球行业研究报告,2020年全球手性化学品市场价值为539.3亿美元,预计到2027年底将达到1013.5亿美元。众所周知,化合物的不同对映体可具有极大不同的生物活性。工业上生产的许多手性化合物都需要对映体纯的形式(仅两种对映体之一),因为监管机构已经认识到化合物的每种对映体在与生物系统(包括人体)相互作用时可能具有不同的作用。这是一个持续的和紧迫的挑战,开发强大的和可靠的方法,生产单一的对映体的化合物,以满足对映体纯的手性化学品的需求。不对称有机催化已经成为一种强大的合成方法,它提供了各种以前无法实现的对映选择性转化,从而产生了各种各样的对映体富集的手性化合物。不对称有机催化利用手性有机分子,主要来自氨基酸,以立体选择性的方式激活另一个分子并促进新键的形成。这项工作的影响使其成为全球公认的关键合成方法,并将2021年诺贝尔奖授予该领域的创始人。 戴维斯小组正在有机催化的前沿工作,开发新的催化剂和反应,这将扩大可以进行的对映选择性反应的类型,并增加可以用这种催化方法产生的手性分子的数量。我们专注于解决该领域的长期问题,包括促进光化学反应的催化剂的开发和进一步从催化剂安装新的键。然后,我们将应用这些方法在合成的生物意义的化合物,证明这些催化方法的强度,在转化为高价值的,工业相关的对映体富集的手性化合物的廉价的非手性原料。这项工作将产生催化方法,这将有助于解决手性化学工业的当前需求,并将产生受过独特培训的研究人员,以解决这个快速增长的经济领域面临的未来挑战。

项目成果

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Davis, Rebecca其他文献

Deep clustering of small molecules at large-scale via variational autoencoder embedding and K-means.
  • DOI:
    10.1186/s12859-022-04667-1
  • 发表时间:
    2022-04-15
  • 期刊:
  • 影响因子:
    3
  • 作者:
    Hadipour, Hamid;Liu, Chengyou;Davis, Rebecca;Cardona, Silvia T.;Hu, Pingzhao
  • 通讯作者:
    Hu, Pingzhao
Can Untrained Patients Perform Their Own Skin and Soft Tissue Ultrasound Examination by Teleguidance?
  • DOI:
    10.24908/pocus.v8i2.16454
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Saati, Ammar;Au, Arthur;Joshi, Aditi U;Davis, Rebecca;West, Frances Mae;Lewiss, Resa E
  • 通讯作者:
    Lewiss, Resa E
Interdisciplinary approach of Yalom's group therapy factors: A theoretical model for including animal presence in social work education and practice.
Yalom的小组疗法因素的跨学科方法:一种在社会工作教育和实践中包括动物存在的理论模型。
  • DOI:
    10.3389/fvets.2022.1024355
  • 发表时间:
    2022
  • 期刊:
  • 影响因子:
    3.2
  • 作者:
    Rusu, Alina Simona;Davis, Rebecca
  • 通讯作者:
    Davis, Rebecca
Wayfinding Strategies and Spatial Anxiety in Older Adults With and Without Alzheimer's Disease
  • DOI:
    10.3928/19404921-20191022-03
  • 发表时间:
    2020-03-01
  • 期刊:
  • 影响因子:
    1.6
  • 作者:
    Davis, Rebecca;Veltkamp, Amy
  • 通讯作者:
    Veltkamp, Amy
TNFα-mediated proliferation of vascular smooth muscle cells involves Raf-1-mediated inactivation of Rb and transcription of E2F1-regulated genes
  • DOI:
    10.4161/cc.11.1.18473
  • 发表时间:
    2012-01-01
  • 期刊:
  • 影响因子:
    4.3
  • 作者:
    Davis, Rebecca;Pillai, Smitha;Chellappan, Srikumar P.
  • 通讯作者:
    Chellappan, Srikumar P.

Davis, Rebecca的其他文献

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{{ truncateString('Davis, Rebecca', 18)}}的其他基金

Design of new Asymmetric, Ion Pairing Catalysis and Reactions
新型不对称离子对催化和反应的设计
  • 批准号:
    RGPIN-2015-04139
  • 财政年份:
    2021
  • 资助金额:
    $ 2.11万
  • 项目类别:
    Discovery Grants Program - Individual
Design of new Asymmetric, Ion Pairing Catalysis and Reactions
新型不对称离子对催化和反应的设计
  • 批准号:
    RGPIN-2015-04139
  • 财政年份:
    2020
  • 资助金额:
    $ 2.11万
  • 项目类别:
    Discovery Grants Program - Individual
Design of new Asymmetric, Ion Pairing Catalysis and Reactions
新型不对称离子对催化和反应的设计
  • 批准号:
    RGPIN-2015-04139
  • 财政年份:
    2019
  • 资助金额:
    $ 2.11万
  • 项目类别:
    Discovery Grants Program - Individual
Design of new Asymmetric, Ion Pairing Catalysis and Reactions
新型不对称离子对催化和反应的设计
  • 批准号:
    RGPIN-2015-04139
  • 财政年份:
    2018
  • 资助金额:
    $ 2.11万
  • 项目类别:
    Discovery Grants Program - Individual
Design of new Asymmetric, Ion Pairing Catalysis and Reactions
新型不对称离子对催化和反应的设计
  • 批准号:
    RGPIN-2015-04139
  • 财政年份:
    2017
  • 资助金额:
    $ 2.11万
  • 项目类别:
    Discovery Grants Program - Individual
Design of new Asymmetric, Ion Pairing Catalysis and Reactions
新型不对称离子对催化和反应的设计
  • 批准号:
    RGPIN-2015-04139
  • 财政年份:
    2016
  • 资助金额:
    $ 2.11万
  • 项目类别:
    Discovery Grants Program - Individual
Design of new Asymmetric, Ion Pairing Catalysis and Reactions
新型不对称离子对催化和反应的设计
  • 批准号:
    RGPIN-2015-04139
  • 财政年份:
    2015
  • 资助金额:
    $ 2.11万
  • 项目类别:
    Discovery Grants Program - Individual

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