ACQUISTION OF A 300 MHZ NMR SPECTROMETER

购买 300 MHZ 核磁共振波谱仪

• 批准号: 6053083
• 负责人: GLENN DOWNES PRESTWICH
• 金额: $ 21.5万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-05-15 至 2001-05-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6053083
• 关键词: biomedical equipment purchase; nuclear magnetic resonance spectroscopy

This proposal requests funds to acquire a Varian Mercury 300 MHz high- resolution NMR spectrometer. This instrument will be housed in The Department of Medicinal Chemistry at The University of Utah (UU) and will serve nine primary biomedical research groups in two departments within the College of Pharmacy (Medicinal Chemistry and Pharmaceutics and Pharmaceutical Chemistry). These research groups comprise over 45 graduate students and postdoctoral associates who rely on daily access to routine NMR for their work in organic synthesis, polymer characterization, and small molecule natural products structure determination. This instrument will replace a 15-year old 200 MHz instrument, and will be the only instrument available for routine small molecule analysis to serve the needs of researchers located within the Health Sciences Center at UU. Minor users from the School of Medicine include the Departments of Radiology, Oncological Sciences, Biochemistry, Physiology, and Human Genetics. The new 300 MHz NMR would be managed by faculty and staff in Medicinal Chemistry and chaired by the Principal Investigator. The NMR Facility Director, Professor Darrell R. Davis, will oversee the instrument purchase and installation, and will coordinate the instrument use, maintenance, and user training.

该提案要求资金购买瓦里安水星300兆赫高分辨率核磁共振光谱仪。该仪器将被安置在犹他大学（UU）的药物化学系，并将服务于药学院两个系（药物化学和药剂学和药物化学）的九个主要生物医学研究小组。这些研究小组由超过45名研究生和博士后组成，他们依靠日常访问的常规核磁共振进行有机合成，聚合物表征和小分子天然产物结构测定的工作。该仪器将取代已有15年历史的200 MHz仪器，并将成为唯一可用于常规小分子分析的仪器，以满足UU健康科学中心研究人员的需求。医学院的次要用户包括放射科、肿瘤科、生物化学系、生理学和人类遗传学。新的300兆赫核磁共振将由药物化学的教职员工管理，并由首席研究员主持。核磁共振设施主任Darrell R. Davis教授将监督仪器的购买和安装，并将协调仪器的使用、维护和用户培训。

项目成果

Cytotoxic Bromoindole Derivatives and Terpenes from the Philippine Marine Sponge Smenospongia sp.

• DOI: 10.1515/znc-2002-9-1027
• 发表时间: 2002-09
• 期刊: Zeitschrift für Naturforschung C
• 作者: D. Taşdemir;T. Bugni;G. C. Mangalindan;G. Concepcion;M. K. Harper;C. Ireland

Cytotoxic isoquinoline quinones from sponges of the genus Petrosia.

来自 Petrosia 海绵的细胞毒性异喹啉醌。

• DOI: 10.1080/1057563031000122130
• 发表时间: 2004
• 期刊: Natural product research.
• 作者: Sandoval,ImeldaT;Davis,RohanA;Bugni,TimS;Concepcion,GiselaP;Harper,MaryKay;Ireland,ChrisM
• 通讯作者: Ireland,ChrisM