ACQUISTION OF A 300 MHZ NMR SPECTROMETER

该提案要求获得资金，以购置一台瓦里安水星300兆赫高分辨率核磁共振光谱仪。该仪器将设在犹他大学(UU)药物化学系，并将为药学院内两个系(药物化学和药物制剂学和药物化学)的九个初级生物医学研究小组提供服务。这些研究小组由超过45名研究生和博士后助理组成，他们在有机合成、聚合物表征和小分子天然产物结构测定方面的工作依赖于日常的核磁共振。该仪器将取代已有15年历史的200 MHz仪器，并将是唯一可用于常规小分子分析的仪器，以满足位于华盛顿大学健康科学中心的研究人员的需求。医学院的次要用户包括放射科、肿瘤科学系、生物化学系、生理学和人类遗传学系。新的300兆赫核磁共振将由药物化学教职员工管理，并由首席研究员担任主席。核磁共振设施主任Darrell R.Davis教授将监督仪器的购买和安装，并将协调仪器的使用、维护和用户培训。

This proposal requests funds to acquire a Varian Mercury 300 MHz high- resolution NMR spectrometer. This instrument will be housed in The Department of Medicinal Chemistry at The University of Utah (UU) and will serve nine primary biomedical research groups in two departments within the College of Pharmacy (Medicinal Chemistry and Pharmaceutics and Pharmaceutical Chemistry). These research groups comprise over 45 graduate students and postdoctoral associates who rely on daily access to routine NMR for their work in organic synthesis, polymer characterization, and small molecule natural products structure determination. This instrument will replace a 15-year old 200 MHz instrument, and will be the only instrument available for routine small molecule analysis to serve the needs of researchers located within the Health Sciences Center at UU. Minor users from the School of Medicine include the Departments of Radiology, Oncological Sciences, Biochemistry, Physiology, and Human Genetics. The new 300 MHz NMR would be managed by faculty and staff in Medicinal Chemistry and chaired by the Principal Investigator. The NMR Facility Director, Professor Darrell R. Davis, will oversee the instrument purchase and installation, and will coordinate the instrument use, maintenance, and user training.