HORMONAL INFLUENCES ON NEURAL-BEHAVIORAL DEVELOPMENT

荷尔蒙对神经行为发育的影响

• 批准号: 2668573
• 负责人: Melissa Hines
• 金额: $ 12.86万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-12-01 至 2001-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2668573
• 关键词: androgens; behavioral /social science research tag; child psychology; clinical research; cognition; congenital adrenal hyperplasia; developmental neurobiology; embryo /fetus toxicology; female; gender difference; hormone regulation /control mechanism; human subject; male; mathematical ability; neural information processing; neuropsychological tests; neuropsychology; preference; self concept; space perception; verbal learning

DESCRIPTION: The role of androgen in the development of cognitive function and neural organization will be evaluated by studying patients with congenital adrenal hyperplasia (CAH), an autosomal recessive disorder causing increased androgen production beginning prenatally. One hundred fifty patients (50 male and 50 female) will be compared to unaffected relatives and to demographically-matched controls. Abilities to be assessed include visuospatial abilities, mathematical abilities, verbal abilities, targeting abilities and general intelligence. Manifestations of neural organization to be assessed include hand preferences and language lateralization. Three competing hypotheses regarding the relationship of prenatal androgen to cognition will be evaluated: 1. Androgen promotes cognitive abilities at which males excel on average (mathematical problem solving, mental rotations abilities, spatial perception and targeting) and impairs those at which female excel on average (verbal fluency and perceptual speed and accuracy); 2. Androgen is associated with general intellectual enhancement; and 3. Androgen is associated with discrepancies between verbal and performance intelligence that have been interpreted to suggest learning disabilities. Hypotheses that prenatal androgen exposure is associated with masculine- typical patterns of neural organization, reflected in reduced right hand preferences and increased language lateralization, will also be assessed. Finally, structural equation models will be used to examine relationships between sex-typed activities in childhood and subsequent patterns of neural organization and cognitive function.

描述：雄激素在发育中的作用 认知功能和神经组织将是 通过对先天性肾上腺患者的研究进行评估 增生性(CAH)，一种常染色体隐性遗传病 从产前开始增加雄激素的产生。150 患者(50名男性和50名女性)将与未受影响的患者进行比较 与亲属和人口统计学上相匹配的对照组有关。未来的能力 评估包括视觉空间能力、数学能力、语言能力 能力、目标能力和一般智力。表现形式 将被评估的神经组织包括手的偏好和 语言的片面化。 关于产前关系的三个相互竞争的假说 雄激素对认知的影响将被评估： 1.雄激素促进男性擅长的认知能力 平均(数学问题解决能力，心理旋转能力， 空间知觉和目标)，并损害女性 优秀的平均水平(语言流畅性和感知速度和准确性)； 2.雄激素与一般智力增强有关；以及 3.雄激素与言语和语言之间的差异有关 已被解释为表明学习的表现智能 残疾人士。 假设产前接触雄激素与男性有关- 神经组织的典型模式，反映在右手缩小 此外，还将评估语言偏好性和语言偏侧化程度。 最后，将使用结构方程模型来检验关系 儿童时期的性行为和随后的性行为模式 神经组织和认知功能。