NOVEL DEGRADABLE POLYMERS FOR ORTHOPEDIC APPLICATIONS

用于骨科应用的新型可降解聚合物

• 批准号: 2653911
• 负责人: KRISTI S. ANSETH
• 金额: $ 10万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-30 至 1998-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2653911
• 关键词: biomaterial compatibility; biomaterial development /preparation; biomechanics; biotransformation; crosslink; laboratory rat; orthopedics; photochemistry; polymerization; polymers

Numerous musculoskeletal applications would benefit from recent advances in the development of safe, strong, easily fashioned, and degradable polymers. For example, treatment of bone fractures through fixation requires the use of materials with sufficient strength to allow fixation, good tissue/material compatibility, and facile molding (into potentially complex shapes) for easy placement by the surgeon. In addition, controlled degradation is imperative to restore optimum bone function upon healing. The material must initially reestablish the mechanical integrity of the bone and subsequently degrade to allow new bone formation to bear load and remodel. This property is a major advantage of degradable polymeric materials over metallic orthopedic devices which shield stresses during healing and can lead to bone atrophy. Degradable polymer implants also eliminate the need for implant retrieval and can be used simultaneously to deliver therapeutic drugs or growth factors. The objective of the proposed research is to develop a new class of degradable polymers that is photopolymerizable and exhibits the desired mechanical properties (particularly as the sample degrades) necessary for orthopedic applications. Development of a photopolymerizable system is beneficial for many reasons including fast curing rates at room temperature, spatial control of the polymerization, and complete ease of fashioning and flexibility during implantation. The polymers will be produced from novel multifunctional monomers (with 3 or more methacrylate groups) that react to produce densely crosslinked networks. The networks will remain biodegradable because the crosslinks will contain -either anhydride or ester linkages, and the rate of degradation will be controlled by changes in the network composition or crosslinking density. With these new materials, studies will be performed to optimize the polymer composition to produce the desired mechanical properties and degradation rates, to attain maximum functional group conversion and minimize volume shrinkage during in vivo curing, and to allow easy placement and handling by the surgeon.

许多肌肉骨骼应用将受益于最近的进展 在开发安全、坚固、易于成型和可降解的 聚合物。例如，通过固定治疗骨折 需要使用具有足够强度的材料来进行固定， 良好的组织/材料兼容性，易于成型(潜在地 形状复杂)，便于外科医生放置。此外，受控 为了在愈合后恢复最佳的骨功能，降解是必不可少的。 该材料必须在最初重新建立 骨骼随后降解以允许新骨形成承受负荷和 重塑模型。这种特性是可降解聚合物的一大优点。 覆盖在金属矫形装置上的材料在 可以治愈，并可能导致骨骼萎缩。可降解聚合物植入物也 无需取出植入物，可同时用于 提供治疗药物或生长因子。建议的目标是 研究是开发一种新型的可降解聚合物，即 可光聚合，并具有所需的机械性能 (尤其是当样本降解时)整形外科所必需的 申请。光聚合体系的开发有利于 原因很多，包括在室温下固化速度快，空间 聚合反应的控制，以及完全易于成型和 植入过程中的灵活性。这些聚合物将由新奇的 反应的多官能团单体(含3个或更多甲基丙烯酸酯基团) 以产生密集的交联型网络。这些网络将继续 可生物降解的，因为交联物将包含-酸酐或 酯的联系，降解率将受到变化的控制 在网络组成或交联度方面。有了这些新的 材料，将进行研究以优化聚合物组成 为了产生所需的机械性能和降解率， 实现最大的官能团转化率和最小的体积收缩 在体内固化过程中，并允许通过 外科医生。