VESTIBULAR TESTING IN DIAGNOSING MENIERES DISEASE

诊断梅尼埃病的前庭测试

• 批准号: 2647890
• 负责人: Steven D. Rauch
• 金额: $ 8.4万
• 依托单位: MASSACHUSETTS EYE AND EAR INFIRMARY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-15 至 2000-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2647890
• 关键词: Meniere's disease; clinical research; diagnosis design /evaluation; diagnostic tests; disease /disorder classification; disease /disorder model; ear disorder diagnosis; human subject; sensory disorder diagnosis; vestibular apparatus

By Current diagnostic criteria, Meniere's disease affects both the hearing and balance components of the inner ear. To date, however, testing of only vestibular function has been unable to distinguish Meniere's disease from other peripheral vestibular pathologies and often even normality. This proposal aims to make two improvements which will solely use vestibular testing to differentiate Meniere's disease from other diagnostic groups and improve our understanding of its pathophysiology. One improvement is to increase the resolving power of vestibular tests. Multivariate statistical methods will be used to extract the key features from the myriad of results that a contemporary vestibular test battery produces. Using these key features, it should be possible to discriminate between a group of patients with Meniere's disease and those with other peripheral vestibulopathies to such an extent that classification of an individual into one of these groups will be improved. The second improvement is to relate the predicted changes in pathophysiology to the predicted changes in the test results. Existing biophysical models will be modified to be consistent with the histopathological data obtained from the temporal bones of Meniere's disease patients and thus provide a basis for the predictions. The feasibility of this approach is demonstrated by preliminary data from only one vestibular test. If successful, this approach will make it possible to increase our understanding about the pathology associated with Meniere's disease itself and to improve the diagnosis of individuals. While this effort concentrates upon Meniere's disease, the general approach can later be expanded to other vestibular disorders.

根据目前的诊断标准，梅尼埃氏病影响的是

项目成果

Multivariate vestibular testing: laterality of unilateral Ménière's disease.

多变量前庭测试：单侧梅尼埃病的偏侧性。

• 发表时间: 2001
• 期刊: Journal of vestibular research : equilibrium & orientation
• 作者: Dimitri,PS;Wall3rd,C;Rauch,SD
• 通讯作者: Rauch,SD

Multivariate vestibular testing: thresholds for bilateral Ménière's disease and aminoglycoside ototoxicity.

多变量前庭测试：双侧梅尼埃病和氨基糖苷类耳毒性的阈值。

• 发表时间: 2001
• 期刊: Journal of vestibular research : equilibrium & orientation
• 作者: Dimitri,PS;Wall3rd,C;Rauch,SD
• 通讯作者: Rauch,SD

Application of multivariate statistics to vestibular testing: discriminating between Menière's disease and migraine associated dizziness.

多变量统计在前庭测试中的应用：区分梅尼埃病和偏头痛相关的头晕。

• 发表时间: 2001
• 期刊: Journal of vestibular research : equilibrium & orientation
• 作者: Dimitri,PS;Wall3rd,C;Oas,JG;Rauch,SD
• 通讯作者: Rauch,SD