MEASUREMENT OF VESTIBULAR FUNCTION IN MENIERE'S DISEASE

梅尼埃病前庭功能的测量

• 批准号: 6379544
• 负责人: Steven D. Rauch
• 金额: $ 20.87万
• 依托单位: MASSACHUSETTS EYE AND EAR INFIRMARY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-04-01 至 2003-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6379544
• 关键词: Meniere's disease; clinical research; ear disorder; ear disorder diagnosis; early diagnosis; evoked potentials; histopathology; human subject; neoplasm /cancer surgery; nerve sheath neoplasm; nystagmus; otocyst /otolith; temporal bone; vertigo; vestibular apparatus; vestibuloocular reflex

DESCRIPTION: (Adapted from the Investigator's Abstract) The overall objective of the investigators is to apply both classic and new measures of vestibular function to the study of Meniere's disease (MD). These measures would enable earlier diagnosis which, in turn, could lead to better treatment response. These methods have the potential to provide a superior means of monitoring the course of the disease and its response to therapy. Finally, these vestibular function measures may provide new insights into the pathophysiology of MD symptoms since they are based upon the physiology of specific parts of the vestibular end-organs. To accomplish these goals, this project will apply vestibular function tests to three groups of subjects: normal controls, subjects with total unilateral vestibular hypofunction (UVH) after acoustic neuroma removal, and MD subjects who, by the nature of their disease, have partial UVH. The three specific aims of this grant are: 1) Characterize the temporal relationship between acute vertigo attacks and long-term loss of vestibular function in MD subjects by correlating results of serial vestibular test batteries with clinical vestibular symptom status; 2) Test the hypothesis that otolith organ dysfunction is an early and consistent finding in MD by applying two new tests of otolith function, positional optokinetic afternystagmus (pOKAN) and vestibular evoked myogenic potentials (VEMP); and 3) Lay the groundwork for detailed clinicopathological studies of the correlation between vestibular function tests and temporal bone vestibular otopathology by soliciting enrollment of study subjects as future temporal bone donors to the NIDCD National Temporal Bone, Hearing and Balance Pathology Resource Registry.

描述：（改编自研究者摘要）总体目标 研究人员的一个新方法是同时应用经典的和新的前庭测量方法， 对梅尼埃病（MD）的研究具有重要意义。这些措施将使 早期诊断，这反过来又可能导致更好的治疗反应。 这些方法有可能提供一种上级的监测手段， 病程及其对治疗的反应。最后，这些前庭 功能测量可能为MD的病理生理学提供新的见解 症状，因为它们是基于特定部位的生理学， 前庭终器为了实现这些目标，本项目将 对三组受试者进行前庭功能测试：正常对照， 受试者完全单侧前庭功能减退（UVH）后，声学 神经瘤切除，和MD受试者谁，由他们的疾病的性质， 部分UVH。该补助金的三个具体目标是：1）描述 急性眩晕发作与长期失代偿时间关系 前庭功能在MD受试者中的相关性研究 临床前庭症状状态成套测试; 2）检验假设 耳石器官功能障碍是MD的早期和一致的发现， 应用两种新的耳石功能测试，位置视动测试， 后眼震（pOKAN）和前庭诱发肌源性电位（VEMP）;以及3） 为详细的相关性临床病理学研究奠定基础 前庭功能测试和颞骨前庭耳病理学之间的关系， 招募研究受试者作为未来的颞骨供体， NIDCD国家颞骨、听力和平衡病理资源登记处。