NOVEL DEGRADABLE POLYMERS FOR ORTHOPEDIC APPLICATIONS

用于骨科应用的新型可降解聚合物

• 批准号: 2617932
• 负责人: KRISTI S. ANSETH
• 金额: $ 6.32万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-05-01 至 2003-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2617932
• 关键词: biomaterial compatibility; biomaterial development /preparation; biomaterial evaluation; biomechanics; biotransformation; crosslink; implant; laboratory rat; orthopedics; photochemistry; polymerization; polymers; tensile strength

DESCRIPTION (Adapted from the Applicant's Abstract): Numerous musculoskeletal applications would benefit from recent advances in the development of safe, strong, easily fashioned and degradable polymers. For example, treatment of fractures through fixation requires the use of materials with sufficient strength to allow fixation, good tissue/material compatibility, and facile molding (into potentially complex shapes) for easy placement by the surgeon. In addition, controlled degradation is imperative to restore optimum bone function upon healing. The material must initially re-establish the mechanical integrity of the bone and subsequently degrade to allow new bone formation to bear load and remodel. This property is a major advantage of degradable polymeric materials over metallic orthopedic devices, which shield stresses during healing and can lead to bone atrophy. Degradable polymer implants also eliminate the need for implant retrieval and can be used simultaneously to deliver therapeutic drugs or growth factors. The objective of the proposed research is to develop a new class of degradable polymers that is photopolymerizable and exhibits the desired mechanical properties (particularly as the sample degrades) necessary for orthopedic applications. Development of a photopolymerizable system is beneficial for many reasons, including fast curing rates at room temperature, spatial control of the polymerization, and complete ease of fashioning and flexibility during implantation. The polymers will be produced from novel multifunctional monomers (with 3 or more methacrylate groups) that react to produce densely cross-linked networks. The networks will remain biodegradable because the cross-links will contain either anhydride or ester linkages, and the rate of degradation will be controlled by changes in the network composition and cross-linking density. With these new materials, studies will be performed to optimize the polymer composition to produce the desired mechanical properties and degradation rates, to attain maximum functional group conversion and minimize volume shrinkage during in vivo curing, and to allow easy placement and handling by the surgeon.

描述（改编自申请人的摘要）：众多 肌肉骨骼应用将受益于最近的进展 开发安全、坚固、易于成型和可降解的聚合物。 为了 例如，通过固定治疗骨折需要使用 具有足够强度以允许固定的材料，良好的组织/材料 兼容性和轻松成型（潜在复杂的形状） 由外科医生放置。 此外，控制降解势在必行 愈合后恢复最佳的骨功能。 该材料必须首先 重建骨骼的机械完整性并随后降解 让新骨形成能够承受负荷和重塑。 此属性是 可降解高分子材料相对于金属矫形材料的主要优点 设备，可以在愈合过程中屏蔽压力，并可能导致骨骼萎缩。 可降解聚合物植入物还消除了植入物取出的需要 并可同时用于输送治疗药物或生长 因素。 拟议研究的目标是开发一个新类别 可降解聚合物，可光聚合并表现出所需的 机械性能（特别是当样品降解时）所需的 骨科应用。 光聚合系统的开发 有益的原因有很多，包括在室温下的快速固化速度 温度、聚合的空间控制以及完全易于 植入过程中的成型和灵活性。 该聚合物将是 由新型多功能单体（具有 3 个或更多甲基丙烯酸酯 基团）反应产生密集的交联网络。 网络 将保持可生物降解，因为交联将包含 酸酐或酯键，并且降解速率将受到控制 通过网络组成和交联密度的变化。 有了这些 新材料，将进行研究以优化聚合物成分 产生所需的机械性能和降解率， 获得最大的官能团转化率并最小化体积收缩 在体内固化过程中，并允许容易地放置和处理 外科医生。