MAGNESIUM SULFATE EFFECTS ON PREGNANT HUMAN UTERUS
MAGNESIUM SULFATE EFFECTS ON PREGNANT HUMAN UTERUS
批准号:
2669661
负责人:
WILLIAM W HURD
金额:
$22.3万
依托单位国家:
美国
项目类别:
财政年份:
1998
资助国家:
美国
项目状态:
已结题
起止时间:
1998-07-01 至 2001-06-30
中文摘要
描述(改编自《调查者摘要》):假设
这一建议是,镁04通过以下方式降低子宫肌层收缩能力
干扰细胞内钙离子的刺激作用
地点。为了验证这一假设,MGS04对特定步骤的影响
在人类子宫肌层的收缩反应中将被评估;这些
研究将包括:1)同时评估收缩力量和
细胞内钙离子测定能力与硫酸镁能力的关系
降低收缩能力,抑制胞浆钙升高;2)
确定MgS04是否抑制磷脂酶C的激活;3)
测定MgS04是否抑制激动剂诱导的蛋白激酶激活
C;以及4)确定MgS04是否抑制肌球蛋白轻链的激活
激活剂。在这些研究中,子宫肌层和培养的子宫
心肌细胞将从剖宫产孕妇身上获得
分娩,不会因感染或药物原因而复杂化
治疗早产。
英文摘要
DESCRIPTION (Adapted from the Investigator's Abstract): The hypothesis of
this proposal is that MgS04 decrease myometrial contractility by
interfering with the stimulatory effect of Ca2+ at intracellular
locations. To test this hypothesis, the effects of MgS04 on specific steps
in the contractile response of human myometrium will be evaluate; these
studies will include: 1) simultaneously evaluating contractile force and
cytosolic Ca2+ to determine the relationship between the ability of MgS04
to decrease contractility and to inhibit increases in cytosolic Ca2+; 2)
determining if MgS04 inhibits activation of phospholipase C; 3)
determining if MgS04 inhibits agonist-induced activation of protein kinase
C; and 4) determining if MgS04 inhibits activation of myosin light chain
kinase. For these studies strips of myometrium and cultured uterine
myocytes will be obtained from pregnant women undergoing cesarean section
deliveries, which are uncomplicated by infection or pharmacologic
treatment for premature labor.
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MAGNESIUM SULFATE EFFECTS ON PREGNANT HUMAN UTERUS
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批准号:6181761
-
项目类别:
-
资助金额:$1.76万
-
财政年份:1998
-
负责人:WILLIAM W HURD
-
依托单位:
MAGNESIUM SULFATE EFFECTS ON PREGNANT HUMAN UTERUS
-
批准号:6364397
-
项目类别:
-
资助金额:$20.44万
-
财政年份:1998
-
负责人:WILLIAM W HURD
-
依托单位:
MAGNESIUM SULFATE EFFECTS ON PREGNANT HUMAN UTERUS
-
批准号:2889537
-
项目类别:
-
资助金额:$21.65万
-
财政年份:1998
-
负责人:WILLIAM W HURD
-
依托单位:
DIRECT EFFECTS OF COCAINE ON THE PREGNANT HUMAN UTERUS
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批准号:2118706
-
项目类别:
-
资助金额:$11.24万
-
财政年份:1991
-
负责人:WILLIAM W HURD
-
依托单位:
DIRECT EFFECTS OF COCAINE ON THE PREGNANT HUMAN UTERUS
-
批准号:3461239
-
项目类别:
-
资助金额:$10.34万
-
财政年份:1991
-
负责人:WILLIAM W HURD
-
依托单位:
DIRECT EFFECTS OF COCAINE ON THE PREGNANT HUMAN UTERUS
-
批准号:3461238
-
项目类别:
-
资助金额:$9.67万
-
财政年份:1991
-
负责人:WILLIAM W HURD
-
依托单位:
DIRECT EFFECTS OF COCAINE ON THE PREGNANT HUMAN UTERUS
-
批准号:2118702
-
项目类别:
-
资助金额:$12.11万
-
财政年份:1991
-
负责人:WILLIAM W HURD
-
依托单位:
DIRECT EFFECTS OF COCAINE ON THE PREGNANT HUMAN UTERUS
-
批准号:2118704
-
项目类别:
-
资助金额:$10.81万
-
财政年份:1991
-
负责人:WILLIAM W HURD
-
依托单位:
海外基金