OSCILLATORS OF THE LEECH HEARTBEAT NEURONAL NETWORK

水蛭心跳神经网络的振荡器

• 批准号: 2775552
• 负责人: Andrew A Hill
• 金额: $ 3.02万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-03-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2775552
• 关键词: Hirudinea; action potentials; alternatives to animals in research; computational neuroscience; computer simulation; heart innervation; heart rhythm; interneurons; invertebrate hormone; neural conduction; neural information processing; neural inhibition; neural transmission; neuropeptides; psychomotor function; voltage /patch clamp; voltage gated channel

Rhythmic motor activity in animals requires that different muscle groups be active with the appropriate phase relations. For example, in a swimming lamprey a traveling lateral wave of body curvature progresses from head to tail. Likewise, in the leech there is a posterior to anterior peristaltic wave of contraction of the heart tubes. In many animals the neural mechanism that controls these motor activities can be described as a chain of segmental oscillators because each segment can produce rhythmic activity in isolation. We have the studied the neuronal network that paces the heartbeat of the leech. This system is particularly amenable to a cellular analysis of the origin of oscillatory neural activity because the neural circuit consists of identified neurons that have been biophysically characterized. The aim of this proposal is to determine the dependence of the inherent cycle periods of segmental oscillators on intrinsic voltage-gated currents and to use computer simulations to help understand the intersegmental coordination of segmental oscillators.

动物的节律性运动活动需要不同的肌肉群 保持适当的相位关系。 例如，在一个 游动的七鳃鳗身体曲率的行进横向波进展 从头到尾。 同样，水蛭也有一个后部 心管收缩的前蠕动波。 在许多 动物控制这些运动活动的神经机制可以 被描述为分段振荡器链，因为每个分段 可以单独产生有节奏的活动。 我们研究了 控制水蛭心跳的神经网络。 这个系统是 特别适合对细胞起源进行分析 振荡神经活动，因为神经回路由 识别出已进行生物物理表征的神经元。目的 该建议的目的是确定固有循环的依赖性 分段振荡器对固有电压门控电流的周期和 使用计算机模拟来帮助理解部门间的关系 分段振荡器的协调。