DROSOPHILA NF2/MERLIN HOMOLOGUE
DROSOPHILA NF2/MERLIN HOMOLOGUE
批准号:
2609541
负责人:
DENNIS R LA JEUNESSE
金额:
$2.62万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1997
资助国家:
美国
项目状态:
未结题
起止时间:
1997-12-01 至
中文摘要
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英文摘要
Neurofibromatosis-2 (NF2) is a dominantly inherited disease that
results in the formation of a wide range of tumors in the nervous
system and associated glial tissues. Recent studies have shown that
the product of the NF2 tumor-suppressor gene is a novel member of the
4.1 protein superfamily called merlin. Functionally, many of these
proteins appear to serve as connections between the cytoskeleton and
cell membrane. While the identification of NF2/merlin as a member of
the protein 4.1 superfamily has been of great interest, it has not
yet led to a specific hypothesis regarding its cellular function or
its role in tumor suppression. A Drosophila merlin homologue
(Dmerlin) has been cloned and sequenced. The overall goal of this
proposal is to use the strengths of the Drosophila system to identify
the functions and interacting partners of merlin. Specifically, l
plan to conduct (1) a structure/function analysis of Dmerlin and (2)
perform screens to identify functionally and physically associated
genes.
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会议论文
Mechanism of Candida albicans rupture on biomimetic NSS
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批准号:9377579
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项目类别:
-
资助金额:$43.64万
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财政年份:2017
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负责人:DENNIS R LA JEUNESSE
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依托单位:
Analysis of Mitochondrial Morphology and Function
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批准号:7305891
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项目类别:
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资助金额:$20.93万
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财政年份:2004
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负责人:DENNIS R LA JEUNESSE
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依托单位:
Analysis of Mitochondrial Morphology and Function
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批准号:6702406
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项目类别:
-
资助金额:$19.35万
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财政年份:2004
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负责人:DENNIS R LA JEUNESSE
-
依托单位:
DROSOPHILA NF2/MERLIN HOMOLOGUE
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批准号:2807474
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项目类别:
-
资助金额:$3.84万
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财政年份:1999
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负责人:DENNIS R LA JEUNESSE
-
依托单位:
DROSOPHILA NF2/MERLIN HOMOLOGUE
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批准号:2262198
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项目类别:
-
资助金额:$2.26万
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财政年份:1996
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负责人:DENNIS R LA JEUNESSE
-
依托单位:
海外基金